Mercodia introduces a new IAPP ELISA to support research into amylin (IAPP) biology, glucose homeostasis, obesity, diabetes, and gut-brain signaling.
Mercodia has launched a new IAPP ELISA (Cat. #10-1352-01) for the quantitative measurement of circulating islet amyloid polypeptide (IAPP), also known as amylin, in human plasma samples. Designed to support exploratory research, the assay combines high sensitivity for low circulating IAPP concentrations with a straightforward workflow requiring no sample pretreatment.
IAPP, also known as amylin, is an anorexic neuroendocrine hormone co-secreted with insulin by pancreatic β-cells. While it has long been recognized for its role in glucose homeostasis, growing evidence suggests that IAPP is involved in a much broader range of physiological processes, including appetite regulation, gastric emptying, energy balance, and gut-brain signaling.
Research interest in IAPP has increased significantly in recent years, driven by the rising prevalence of obesity, diabetes, and other metabolic disorders. Scientists are increasingly exploring the role and relevance of IAPP in metabolic health and disease.
In addition to its primary production in the pancreas, IAPP is also expressed in specific brain regions, the gastrointestinal tract, pulmonary tissue, and the central nervous system, highlighting its diverse biological functions and systemic impact.
IAPP is released alongside insulin after nutrient stimulation and helps regulate postprandial metabolism. The hormone has been shown to suppress glucagon secretion, slow gastric emptying, influence satiety signaling, and regulate food intake through both peripheral and central mechanisms.
As understanding of the gut-brain axis continues to evolve, IAPP is increasingly being investigated for its role in connecting pancreatic function, appetite regulation, and energy balance. Studies have also suggested potential links between IAPP biology and leptin sensitivity, further highlighting its relevance in obesity research.
Beyond metabolic regulation, ongoing research is investigating the involvement of IAPP in neurological and neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease, making this peptide an increasingly interesting target for translational research.
Because endogenous IAPP circulates at low concentrations and has a short half-life, sensitive and specific analytical methods are essential for generating reliable data and understanding its biological role.
As interest in IAPP research continues to grow, so does the need for reliable tools for quantifying circulating IAPP in human samples.
To support researchers in this rapidly expanding field, Mercodia has launched a new On-demand IAPP ELISA for the quantitative measurement of IAPP in human plasma.
The assay is a two-site sandwich immunoassay utilizing monoclonal antibodies targeting distinct epitopes on IAPP. In addition to mature IAPP, the assay has demonstrated detection of the processing intermediate proIAPP(1-48), supporting broader assessment of circulating IAPP-related molecules.
The assay has been analytically characterized for exploratory research use and combines high sensitivity with a straightforward workflow. No sample pretreatment is required, making it suitable for studies investigating diabetes, obesity, cardiometabolic disease, and gut-brain signaling.
Mercodia’s On-demand IAPP ELISA can help your laboratory investigate circulating amylin biology with a sensitive, specific, and easy-to-use assay for human plasma samples. With no sample pretreatment required, a low sample volume, and chemiluminescent detection, this ELISA is designed to support reliable exploratory research into glucose homeostasis, obesity, diabetes, cardiometabolic disease, and gut-brain signaling.
Contact our technical support team for more information on how this assay can support your metabolic research workflow. To place an order, reach out to your Bio-Connect account manager or request the Mercodia On-demand IAPP ELISA (Cat. #10-1352-01) directly through our request form.
A novel Islet Amyloid PolyPeptide (IAPP) ELISA for specific determination of IAPP in human samples
IAPP (Amylin): A gut-brain axis hormone involved in metabolic regulation
ELISAs (IVD and RUO) | Assay Development | Controls | Manufacturing & Sample Analysis Services
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