Cytokeratins as tumor markers
Cytokeratins are particularly useful tools in oncology diagnostics.
Targeting cancer stem cells is a therapeutic strategy that holds hope for the improvement of patients’ survival.
Cancer stem cells (CSCs) are a small number of cells, usually 1% to 3% of all cells in a tumor, that drive the tumor’s initiation, growth and metastasis, and may cause relapse. Due to their importance, several biomarkers that characterize CSCs have been identified, allowing diagnostic, therapeutic, and prognostic predictions. Thus, selectively targeting CSCs with various agents holds hope for improvement of cancer patients’ survival and is a promising therapeutic strategy against cancer. This white paper provides an overview of the most prominent CSC markers, focusing on solid cancers (lung, stomach, liver, breast, and colorectal cancers) and hematological cancers (acute and chronic myeloid leukemias).
A complete defined and animal-component free cell culture solution designed for the selective culture of malignant cells derived from primary tumors or patient-derived xenografts.
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