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MCE Recombinant Proteins

MedChemExpress (MCE) provides a wide range of high-quality recombinant proteins, including cytokines, enzymes, growth factors, hormones, receptors, transcription factors, and antibody fragments. These proteins are crucial for cell growth, signaling, and differentiation, and are vital tools for studying protein structure and function, disease mechanisms, and drug targets.

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Over 12,000 recombinant protein products

Key Features:

• Superior purity: surpassing 95%
• Outstanding bioactivity
• Excellent lot-to-lot consistency
• Low endotoxin levels: <1 EU/μg 
• Flexible package size options available (From 2μg-1mg)

MCE has always been dedicated to providing top-quality products. Through a stringent quality control system and robust quality assurance processes, MCE ensures that the recombinant proteins exhibit outstanding characteristics, exceptional purity, and optimal biological activity, all of which meet the highest standards.

High Purity

The purity of MCE’s mouse IL-13Rα₂ exceeds 95%, as determined by SDS-PAGE under reducing conditions and HPLC analysis.

Superior Bioactivity

MCE’s human GM-CSF promotes the proliferation of TF-1 cells, with an ED₅₀ of less than 0.5 ng/mL.

Excellent Lot-to-Lot Consistency

The ED50 values of MCE’s human VEGF165 from three distinct lots are highly consistent.

Activity Comparison

A side-by-side comparison of the ED50 values shows that MCE’s human VEGF165 is more potent than that of a competitor brand.

Category	Product Name
Cytokines and Growth Factors (3000+) MedChemExpress (MCE) provides a range of cytokines and growth factors, including interleukins, chemokines, interferons, transforming growth factors, fibroblast growth factors, as well as the cytokine receptor family.	IL-2 Protein	IFN-gamma Protein
	TGF beta 1 Protein	EGF Protein
Immune Checkpoint Proteins (550+) Covering a series of immune checkpoint molecules, including PD-1/PD-L1, CTLA-4, TIM-3, OX40, TIGIT, and novel immune checkpoint proteins such as butyrophilins (BTNs).	PD-1 Protein	PD-L1 Protein
	CTLA-4 Protein	CD40 Protein
CAR-T Related Proteins (350+) Covering popular targets, including BCMA, CD19, MSLN, HER2, MUC1, CD22, ROR1, and providing labeled target antigens, such as fluorescently labeled and biotin-labeled, to support CAR-T research and development.	BCMA/TNFRSF17 Protein	CD19 Protein
	EpCAM/TROP1 Protein	HER3 Protein
CD Antigens (1900+) CD molecules function as cell adhesion molecules, cytokine receptors, ion channels, or nutrient transport proteins, playing various roles in immune system function. CD molecules are commonly used as cell markers for immune antigen recognition.	CD3 epsilon Protein	CD8 beta Protein
	B7-1/CD80 Protein	CD4 Protein
Receptor Proteins (1700+) Receptor proteins include enzyme-linked receptors, cell adhesion molecules, G protein-coupled receptors, nuclear receptors, pattern recognition receptors, Notch, and other receptor families.	GLP1R Protein	TrkB Protein
	PVR/CD155 Protein	Siglec-15 Protein
Fc Receptors (120+) The binding activity between the Fc fragment of antibodies and receptors affects the efficacy of antibody drugs. MedChemExpress (MCE) offers a range of high-quality recombinant Fc receptor proteins for antibody drug modification and evaluation, facilitating the development of antibody drugs.	FcRn Protein	Fc Receptor-like Proteins
	Fc-gamma Receptor Protein	Fc gamma RII/CD32 Proteins
Enzymes & Regulators (3100+) Most biological processes in organisms are regulated by enzymes. MedChemExpress (MCE) provides a variety of enzyme-related proteins, including various families of enzymes and inhibitors, such as MMPs, proteases, CDKs, phosphatases, protease inhibitors, kinase inhibitors, and CDK inhibitors.	Cathepsin A Protein	ACE2 Protein
	MMP-9 Protein	Aminopeptidase N/APN Protein
Complement System (80+) MedChemExpress (MCE) has developed a series of high-quality recombinant proteins, including C3, C5, MASP, complement regulatory factors, etc., to support research on the complement system mechanism and related diseases.	Complement C3/C3a Protein	Complement C5/C5a Protein
	CFHR2 Protein	CFHR1 Protein
Ubiquitin Related Proteins (200+) Ubiquitination regulates various cellular processes, including cell division and differentiation, responses to environmental stress, cell differentiation, immune reactions, DNA repair, and apoptosis.	UCHL1 Protein	USP14 Protein
	KEAP1 Protein	UBE2I Protein
Biotinylated Proteins (600+) MedChemExpress (MCE) has developed nearly a thousand recombinant biotinylated and Avi-Tag proteins, which can be used in protein purification, protein-protein interactions, detection, screening, and other research applications.	PCSK9 Protein (Biotinylated)	PD-L1 Protein (Biotinylated)
	Siglec-15 Protein (Biotinylated)	CD79B Protein (Biotinylated)
Fluorescent-labeled Recombinant Proteins (60+) Fluorescent labeling is a versatile tool for studying molecular interactions, tracking protein movement, and probing protein biological functions.	FITC-Labeled CD47 Protein	PE-Labeled Mesothelin Protein
	FITC-Labeled HGFR Protein	FITC-Labeled CD99 Protein
Viral Proteins (1000+) MedChemExpress (MCE) provides a variety of recombinant viral proteins, including influenza viruses, coronaviruses, HIV, hepatitis viruses, and more, to support research on viral infections.	SARS-CoV S Protein	SARS-CoV-2 S Protein
	NA/Neuraminidase Protein	MERS-CoV Spike/S1 Protein
GMP-grade Proteins (30+) MedChemExpress (MCE) GMP recombinant proteins are manufactured under specific guidelines to ensure product quality and consistency. Each lot of our GMP-grade recombinant proteins undergoes rigorous QC testing tests.	GMP IL-4 Protein	GMP EGF Protein
	GMP FLT3LG Protein	GMP IL-18 Protein
Animal-free Recombinant Proteins (270+) Animal-free recombinant proteins have the same biological activity as proteins produced using standard laboratory techniques, while researchers do not have to worry at all about traces of animal components or mammalian pathogens affecting their experiments.	Animal-Free Beta-NGF Protein	Animal-Free IFN-beta Protein
	Animal-Free IGF2 Protein	Animal-Free IL-17A Protein

Customer Validation

Cited in: Adv Sci (Weinh). 2024 Jun 20:e2404171.

TNF-α (HY-P7058) treatment upregulates the expression of adhesion molecules on the surface of HUVECs. Additionally, by increasing the expression of CXCR4 and VLA-4, it enhances the inflammatory chemotaxis of MMCLs, greatly improving their transendothelial migration efficiency.

Recombinant Protein Expression Services

Special Topic

Organoid Culture

An organoid is a 3D multicellular in vitro tissue construct that mimics the complex structure and functionality of corresponding in vivo organ. MedChemExpress (MCE) provides a range of cytokines, small molecule inhibitors, basement membrane matrix, and various organoid culture kits

Immune Checkpoint Proteins

ICPs have been identified and studied in cancer, including PD-1, CTLA-4, LAG3 and TIGIT, etc. MedChemExpress (MCE) offers recombinant proteins, specific small molecule inhibitors/agonists, and antibody inhibitors for immune checkpoint research.

SARS-CoV-2

SARS-CoV is a positive-stranded RNA virus belonging to the family Coronaviridae. The SARS-COV-2 genome encodes at least sixteen non-structural proteins and four structural proteins.

Stem Cell Related Research

Stem cells are able to differentiate into different types of cells in the body and have unique abilities to self-renew and recreate functional tissues. MedChemExpress (MCE) offers a range of products related to stem cell culture.

Matrix Metalloproteinases

MMPs are widely involved in a variety of physiological and pathological processes, and plays an important role in cell migration, tissue remodeling, etc. MMPs have emerged as significant biomarkers and therapeutic targets in clinical diagnostics and treatment.

Cytokines for Immune Cell Culture

Immune cell culture models are essential tools in immunology research. MCE can provide a range of high-quality cytokines for the in vitro culture, activation, and differentiation of various immune cells, to enhance the controllability and reproducibility of immune cell cultures.