22 February 2022

Verified superior biological activity – Recombinant Proteins

MedChem Express currently produces more than 7,000 kinds of recombinant proteins, including cytokines, immune checkpoint proteins, CAR-T related proteins, CD antigens, receptor proteins, enzymes, etc.

Recombinant protein is a protein encoded by a recombinant DNA that has been cloned in a system that supports the expression of the gene and translation of mRNA. Recombinant proteins have been widely used in most hot research areas such as immune checkpoints, antibody-drug targets, CAR-T cell therapy targets, Fc receptors, influenza viral proteins and cytokines.

MedChem Express (MCE) currently produces and sells more than 7,000 kinds of recombinant proteins, including cytokines, immune checkpoint proteins, CAR-T related proteins, CD antigens, receptor proteins, enzymes, biotinylated proteins, ubiquitin related proteins, etc. All of MCE products are produced with various tags, multiple species, excellent lot-to-lot consistency, superior activity and significantly low endotoxin, which can meet the needs of different customers.

So far, publications citing use of MCE recombinant proteins involve various popular fields of cell growth and differentiation, cell signaling, biopharmaceutical target discovery, protein structure and function analysis, etc.

MCE always provide the high-quality products, good pre-sales and after-sales services, MCE has become a trusted experimental partner for millions of scientists and technicians worldwide.

Regulation of (myo)fibroblast differentiation and activation. Primary mouse pulmonary fibroblasts are treated with HY-P7117 TGF-β1 to induce (myo)fibroblastic differentiation. The mRNA levels of PTPN13 and NOX4 in the (myo)fibroblasts are significantly elevated after treated, accompanied by an increase in the expression of the (myo)fibroblast marker protein α-SMA.
Usage Cited in Theranostics. 2021 Jan 9;11(7):3244-3261.

Liver organoids derived from bipotent EpCAM+ human liver cells. Organoids cultured supplement with HY-P7114 R-spondin 1, HY-P7008 BMP-7, HY-10432 A 83-01, HY-10182 CHIR-99021, HY-15371 Forskolin, HY-10071 Y-27632. A. DIC imageand. B. Immunofluorescent confocal microscopy imaging showing epithelial cell adhesion molecule (EpCAM).
Usage Cited in Front Med (Lausanne). 2021 Sep 23;8:746298.

Publications citing use of MCE products

Cell Death Differ. 2021 Jan;28(1):219-232.
Biomaterials. 2021 Jan;265:120392.
J Exp Clin Cancer Res. 2020 Jun 23;39(1):119.
Cell Rep. 2020 Jan 7;30(1):98-111.e5.
J Control Release. 2021 Jul 26;S0168-3659(21)00383-7.
Front Cell Dev Biol. 2021 Jun 14;9:679658.
Cancers. 2020 Mar 16;12(3):702.
Oxid Med Cell Longev. 2021 Jan 16;2021:5986260.
Aging. 2021 Feb 11;13(4):5650-5673.
Small. 2020 Jun;16(22):e2001371.
Acta Pharm Sin B. 2020 Sep;10(9):1619-1633.
Cell Rep. 2021 Jan 5;34(1):108576.
Acta Biomater. 2020 Jan 1;101:152-167.
Cell Death Dis. 2021 Apr 14;12(4):397.
Biochem Pharmacol. 2021 Jun;188:114578.
Cell Death Dis. 2020 Nov 4;11(11):950.
Cells. 2020 Mar 15;9(3):722.
Cell Commun Signal. 2019 Aug 14;17(1):94.

Verified superior biological activity – Recombinant Proteins

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