Invivoscribe

PCR | B- & T-cell clonality assays (IGH, IGK, TRG, TRB) | Chromosome Translocations | CDx FLT3 Mutation Assay | NGS Gene Panels | MRD clonality solutions | Molecular Biology | Services for Oncology Testing

Invivoscribe® is a global technology-driven cancer diagnostics company. Our mission is to optimize patient care and accelerate drug approvals worldwide by providing best-in-class products and services.

Invivoscribe provides a comprehensive selection of PCR-based products, including B- & T-cell clonality assays (IGH, IGK, TRG, TRB), chromosome translocations, the LeukoStrat® CDx FLT3 Mutation Assay, NGS gene panels and minimal residual disease (MRD) solutions with bioinformatics software.

Invivoscribe solutions are available as research use only testing reagents and controls as well as CE-marked in vitro diagnostic products.

Improving Lives with Precision Diagnostics®

Bio-Connect supplies all their products in the Benelux. If you have any questions, please contact the helpdesk.

Major product lines from Invivoscribe

  • LymphoTrack® Dx (B- and T-cell clonality NGS Assays)
  • LeukoStrat® CDx FLT3 Mutation Assay
  • IdentiClone® (B- and T-cell clonality, FLT3 and translocation ABI Fluorescence Detection Assays)
  • MRD clonality solutions
  • FLT3 ITD MRD and NPM1 MRD Assays
  • Gene translocations
  • DNA and RNA controls, sensitivity- and proficiency-panels

Generating clinically actionable results that optimize treatments

Invivoscribe’s assays inform and guide the patient’s physician from diagnosis through the entire course of therapy.

 

Top sellers

Publications

  • J Mol Diagn. 2022;24(1):48-56.

    Ha J, Lee H, Shin S, et al. Ig gene clonality analysis using next-generation sequencing for improved minimal residual disease detection with significant prognostic value in multiple myeloma patients.

  • J Mol Diagn. 2021;23(2):181-199.

    Ho C, Syed M, Roshal M, et al. Routine evaluation of minimal residual disease in myeloma using next-generation sequencing clonality testing: feasibility, challenges, and direct comparison with high-sensitivity flow cytometry.

  • Case Rep Hematol. 2021;2021:9740281.

    Kadkol SS, Bland J, Kavanaugh A, Ni H, Nehru V, Peace D. Ngs analysis of clonality and minimal residual disease in a patient with concurrent richter’s transformation and cll/sll.

  • PLoS One. 2021;16(6):e0253541.

    Kim M, Jeon K, Hutt K, et al. Immunoglobulin gene rearrangement in Koreans with multiple myeloma: Clonality assessment and repertoire analysis using next-generation sequencing.

  • J Mol Diagn. 2021;23(7):805-815.

    Ho CC, Tung JK, Zehnder JL, Zhang BM. Validation of a next-generation sequencing-based t-cell receptor gamma gene rearrangement diagnostic assay: transitioning from capillary electrophoresis to next-generation sequencing.

  • J Hematol Oncol. 2018;11(1):105.

    Cheng S, Inghirami G, Cheng S, Tam W. Simple deep sequencing-based post-remission MRD surveillance predicts clinical relapse in B-ALL.

  • Leukemia. 2017;31(4):837-845.

    Stamatopoulos B, Timbs A, Bruce D, et al. Targeted deep sequencing reveals clinically relevant subclonal IgHV rearrangements in chronic lymphocytic leukemia.

  • Blood Adv. 2018;2(8):825-831.

    Levis MJ, Perl AE, Altman JK, et al. A next-generation sequencing-based assay for minimal residual disease assessment in AML patients with FLT3-ITD mutations.

  • J Mol Diagn. 2019;21(2):330-342.

    Arcila ME, Yu W, Syed M, et al. Establishment of immunoglobulin heavy (Igh) chain clonality testing by next-generation sequencing for routine characterization of b-cell and plasma cell neoplasms.

  • Front Oncol. 2019;9:449.

    Yao Q, Bai Y, Orfao A, Chim CS. Standardized minimal residual disease detection by next-generation sequencing in multiple myeloma.

Videos

Invivoscribe Corporate Video

Custom services

Invivoscribe is a specialist in standardized molecular assays for hematologic malignancies and offers advanced custom assay and biomarker solutions for oncology and precision medicine programs. Their custom capabilities include biomarker assay development on PCR and NGS platforms, from early concept through design, optimization, and validation, and the development of custom gene panels based on their MyAML®, MyHeme®, and MyMRD® technologies. In addition, Invivoscribe engineers bespoke positive and negative controls tailored to specific targets, platforms, and sensitivity requirements.

Invivoscribe also develops and manufactures clonality, MRD, and mutation assays together with associated bioinformatics software, and has extensive experience in companion diagnostics (CDx) development in partnership with pharmaceutical companies.

Beyond assay design, Invivoscribe provides integrated product development and manufacturing services that cover assay development for investigational use (IUO), research-use assays, CE marked IVDs, and CDx, along with regulatory and quality support. This enables assay developers and drug development teams to work with a single partner from early biomarker concept through to commercial ready kits and controls for clinical testing laboratories.

Through Bio Connect, customers in the Benelux can access Invivoscribe’s custom biomarker assay, gene panel, and control development solutions with local scientific and logistical support. Our team helps define your clinical and assay requirements, coordinates the custom development and manufacturing workflows with Invivoscribe, and ensures reliable delivery of high quality, fit for purpose assays and reagents tailored to your research, drug development, and molecular diagnostics workflows.

More about Invivoscribe

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