Cytokines are crucial for stem cell renewal and differentiation. Sino Biological offers high-quality and GMP-grade recombinant cytokines, with high bioactivity, lot-to-lot consistency, and purity.
Stem cells are pivotal for medical advancements, harnessing crucial cytokines such as SCF, IL-6, EGF, BMP-2, FGF, VEGF-A, and more to regulate their renewal and differentiation. Current trends emphasize using stem cells for regenerative medicine, disease modeling, and drug discovery, with unparalleled potential to regenerate damaged tissues, treat diseases like Parkinson’s and diabetes, and understand complex biological processes. Sino Biological propels this field forward by providing essential GMP- and RUO-grade cytokines for stem cell research.
Products Highlights
High purity: Purity >95% by SDS-PAGE & HPLC
High bioactivity: Validated by ELISA, cell-based assays
Low endotoxin: 5-10 EU/mg
High lot-to-lot consistency
Vast selection: Covers both research grade and GMP grade cytokines
Quality control: ISO 9001/ISO 13485/GMP quality systems
Exploring Stem Cell Culture Cytokines by Cell Type
Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are adult stem cells found in various tissues such as umbilical cord, bone marrow, and adipose tissue. They have the remarkable ability to self-renew and differentiate. Sino Biological provides cytokines, marker antibodies, and identification kits for MSC culture to support MSC research and development.
Cytokines involved in MSCs differentiation
Product Validation Data
GMP-grade Human FGF2 (Cat#: GMP-10014-HNAE) High bioactivity
Cell proliferation assay using Balb/c 3T3 mouse embryonic fibroblasts.
Human PDGF-BB Protein (Cat#: 10572-HNAE)
High homodimer purity
Cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblasts.
High batch-to-batch consistency
Cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblasts.
Human EGF Protein (Cat#: 10605-HNAE)
High purity
≥ 95 % as determined by SDS-PAGE and SEC-HPLC.
High bioactivity
Cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblasts.
High batch-to-batch consistency
Cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblasts.
Embryonic and Induced Pluripotent Stem Cells
Both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are pluripotent stem cells with unlimited self-renewal capacity and the potential to differentiate into any cell type. Cytokines and growth factors, including GM-CSF, Activin A, DLL4, NOG, TNF-α, IL-2, VEGF, FGF, IL1β and EGF, are essential components for the differentiation of human iPSCs into various cell lines.
Schematic overview of cytokines involved in ESC/iPSC differentiation.
Product Validation Results
Human EGF Protein: 10605-HNAE
High-purity
≥ 95 % as determined by SDS-PAGE & SEC-HPLC.
High batch-to-batch consistency:
Cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblasts.
Human vascular organoids derived from iPSCs were cultured using FGF2, VEGFA, and EGF. The vascular organoids are indicated by red arrows.
Hematopoietic Stem Cells
HSCs are multipotent stem cells that can self-renew and differentiate multidirectionally into various types of blood cells, including both myeloid and lymphoid lineages. Sino Biological offers cytokines for HSC culture, including GMP-grade options, to comprehensively support HSC research.
Schematic overview of cytokines involved in HSC differentiation.
Product Validation Results
GMP-grade, Animal-Free Human SCF (Cat#: GMP-10451-HNAE1-L-AF)
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
GMP-grade, Animal-Free Human IL-21 (Cat#: GMP-10584-HNAE1-L-AF)
Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells.
Neural Stem Cells
Neural stem cells (NSCs) reside within the nervous system and are capable of self-renewal and differentiation into neurons, astrocytes, and oligodendrocytes. Under specific conditions, NSCs differentiate into these functional cells, replenishing lost cells and restoring function. This ability is crucial for neural development and the repair of damaged neural tissues.
Schematic overview of cytokines involved in NSC differentiation.
Product Validation Results
Human VEGF165 Protein (Cat#:11066-HNAH)
Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC).
Human Noggin/NOG Protein (Cat#: 10267-HNAH)
Measured by its ability to inhibit BMP4-induced alkaline phosphatase production by MC3T3E1 mouse preosteoblast cells.
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