23 June 2021

Immune checkpoint antibodies

Bio X Cell offers an extensive selection of antibodies targeting mouse immune checkpoint proteins


Immune checkpoints are regulators of the immune system which prevent the immune system from attacking self-antigens indiscriminately. While this is critical to preventing auto-immune disease it also causes the immune system to be ineffective in eradicating or suppressing cancer.

Tumor cells exploit certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. Because many of these immune checkpoints are initiated by ligand-receptor interactions, they can be readily blocked by antibodies.

Blocking these immune checkpoints allows antitumor activity to resume and is among the most promising approaches to activating therapeutic anti-tumor immunity.

Immune checkpoint pathways

Selected immune checkpoint antibodies from Bio X Cell

InVivoMab anti-mouse CTLA-4 (CD152) (BE0131)
InVivoPlus anti-mouse CTLA-4 (CD152) (BP0131)
InVivoMab anti-mouse CTLA-4 (CD152) (BE0164)
InVivoPlus anti-mouse CTLA-4 (CD152) (BP0164)
InVivoMab anti-mouse CTLA-4 (CD152) (BE0032)
InVivoPlus mouse CTLA-4 (CD152) (BP0032)
InVivoMab anti-mouse 4-1BB (CD137) (BE0169)
InVivoPlus anti-mouse 4-1BB (CD137) (BP0169)
InVivoMab anti-mouse CD137 (4-1BB) (BE0239)
InVivoMAb anti-mouse 4-1BB (CD137) (BE0296)
InVivoMab anti-mouse 4-1BBL (CD137L) (BE0110)
InVivoMab anti-mouse CD40 (BE0016-2)
InVivoPlus anti-mouse CD40 (BP0016-2)
InVivoMab anti-mouse CD154 (CD40L) (BE0017-1)
InVivoPlus anti-mouse CD154 (CD40L) (BP0017-1)
InVivoMab anti-mouse CD47 (IAP) (BE0270)
InVivoMab anti-human/mouse/rat CD47 (BE0283)
InVivoMab anti-mouse B7-1 (CD80) (BE0134)
InVivoMab anti-mouse CD80 (B7-1) (BE0024)
InVivoMab anti-mouse CD86 (B7-2) (BE0025)
InVivoMab anti-mouse B7-H3 (BE0124)
InVivoMab anti-mouse LAG-3 (BE0174)
InVivoPlus anti-mouse LAG-3 (BP0174)
InVivoMab anti-mouse OX40 (CD134) (BE0031)
InVivoPlus anti-mouse OX40 (CD134) (BP0031)
InVivoMab anti-mouse OX40L (CD134L) (BE0033-1)
InVivoMab anti-mouse PD-1 (CD279) (BE0146)
InVivoPlus anti-mouse PD-1 (CD279) (BP0146)
InVivoMab anti-mouse PD-1 (CD279) (BE0273)
InVivoPlus anti-mouse PD-1 (CD279) (BP0273)
InVivoMab anti-mouse PD-1 (CD279) (BE0033-2)
InVivoPlus anti-mouse PD-1 (CD279) (BP0033-2)
InVivoMab anti-mouse PD-L1 (B7-H1) (BE0101)
InVivoPlus anti-mouse PD-L1 (B7-H1) (BP0101)
InVivoMab anti-mouse PD-L2 (B7-DC) (BE0112)
InVivoMAb anti-mouse TIM-1 (CD365) (BE0289)
InVivoMab anti-mouse TIM-1 (CD365) (BE0113)
InVivoMAb anti-mouse TIM-1 (CD365) (BE0314)
InVivoMab anti-mouse TIM-3 (CD366) (BE0275)
InVivoPlus anti-mouse TIM-3 (CD366) (BP0115)
InVivoMab anti-mouse TIM-3 (CD366) (BE0115)
InVivoMAb anti-mouse VISTA (BE0310)
InVivoPlus anti-mouse VISTA (BP0310)
InVivoMab anti-mouse ICOS (BE0059)
InVivoPlus anti-mouse GITR (BP0063)
InVivoMab anti-mouse GITR (BE0063)
InVivoMab anti-mouse Galectin-9 (BE0218)
InVivoMAb anti-mouse CD27 (BE0348)
InVivoMab anti-mouse CD28 (BE0015-1)
InVivoMab anti-mouse CD28 (BE0015-5)
InVivoMAb anti-mouse CD28 (BE0328)
InVivoMab anti-mouse CD70 (BE0022)
InVivoMab anti-mouse ICOSL (CD275) (BE0028)
InVivoMab anti-mouse BTLA (CD272) (BE0132)
InVivoMab anti-mouse BTLA (CD272) (BE0153)
InVivoMab anti-mouse BTLA (CD272) (BE0196)
InVivoMAb anti-mouse FGL-1 (BE0332)
InVivoMAb anti-mouse FGL-1 (BE0332)
InVivoMab anti-mouse PSGL-1 (CD162) (BE0186)
InVivoMab anti-mouse TIGIT (BE0274)
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