4 August 2022

Unique specific human IL-37 ELISA for biological aging research

AdipoGen Life Sciences offers the only specific human IL-37 ELISA Kit, as recently described in an independent academic study, suggesting a possible role of IL-37 in biological aging in humans!


Interleukin-37 declines with aging in healthy humans

IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. The IL-37 levels increase to modulate inflammation in several pathophysiological states, including obesity, insulin resistance, and the metabolic syndrome, as well as in aging. Increased baseline inflammation is a feature of aging organisms and tissues and the role of IL-37 in the context of human physiological aging has not been studied.

In a recent study, the lab of Prof. Douglas R. Seals (University of Colorado Boulder, USA) reports in the journal GeroScience an investigation on the role of IL-37 in the context of human physiological aging and compared the levels of IL-37 in young, middle-aged and older adults using the IL-37 (human) ELISA Kit from Adipogen Life Sciences. The IL-37 (human) ELISA Kit has first been validated and its accuracy, reproducibility and specificity confirmed in an independent setting. In this study they observe that circulating concentrations of IL-37 are lower in older compared with younger adults, despite chronic low-grade elevations in pro-inflammatory cytokines in older adults. This suggests that older adults do not mount an appropriate plasma IL-37 response to combat age-related increases in circulating pro-inflammatory markers.

This study provides evidence that IL-37 concentrations decline in older age and are related to selective markers of healthspan in healthy humans and suggests a possible role of IL-37 in biological aging in humans.

Unique reagents to study human IL-37 in vitro and in vivo

IL-37 (human) ELISA Kit (AG-45A-0041YEK)
IL-37 (human) (rec.) (His) (AG-40A-0174Y)
IL-37 (aa46-218) (human) (rec.) (His) (AG-40A-0190)
IL-37 (human) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0221)
anti-IL-37 (human), pAb (AG-25A-0111)

Reference

Unique specific human IL-37 ELISA for biological aging research

Related articles

Newsletter for researchers

We gladly support you by keeping you updated on our latest products and the developments around our services.

Need help? Contact our technical support
Contact