Absolute Antibody

Specialists in antibody sequencing, engineering, and recombinant manufacturing.


Engineered recombinant antibodies to advance your research.

Absolute Antibody was founded in 2012 with a vision to make engineered recombinant antibodies accessible to all, and they remain the only company 100% focused on recombinant antibody technology. They offer antibody sequencing, engineering and recombinant production as custom services, as well as a unique catalog of recombinant antibodies and Fc Fusion proteins, engineered into new and useful formats.

In 2022, they became part of Absolute Biotech, a new company that unites multiple life science brands into one organization specializing in antibody reagents and services, who also has a number of other brands such as: ExalphaLSBioNordic-MUBio, Kerafast and Everest Biotech. Bio-Connect Life Sciences supplies all brands in the Benelux. If you have any questions, please contact the helpdesk.

Major product lines from Absolute Antibody

  • Engineered recombinant antibodies for research areas including immunotherapy, virology, and allergies
  • VivopureX™ – mouse anti-mouse antibodies for in vivo studies
  • Biosimilars
  • Bispecific antibody reagents
  • Isotype controls in a multitude of formats
  • Anti-tag antibodies
  • Anti-DNA and RNA antibodies

Why go recombinant?

Though recombinant antibodies are standard in the pharmaceutical industry, these antibodies have not been as widely available for diagnostics or research. This is starting to change, however, due to the many advantages recombinant antibodies offer over traditional hybridoma-produced monoclonal antibodies.

The vast majority of reagent monoclonal antibodies are generated from hybridomas, immortal antibody-producing cells created by fusing a tumor (myeloma) cell with an antibody-producing B cell from an immunized animal. However, hybridomas suffer from many limitations. They can undergo genetic drift, leading to batch-to-batch variability; they can be genetically unstable and stop expressing the antibody; and more than 30% of hybridomas contain additional antibody genes, meaning they are not actually monoclonal.

In contrast, recombinant antibodies are manufactured using synthetic genes expressed in a defined in vitro cell line. They offer a variety of benefits compared to traditional hybridoma-produced antibodies.

  • Ensured reproducibility
  • Biological definition
  • High purity
  • Added antibody value via antibody engineering
  • Animal-free manufacturing
  • Security

Custom Antibody Services

In addition to a recombinant antibody catalog, Absolute Antibody offers antibody sequencing, antibody engineering, and recombinant antibody expression as custom services. Absolute Antibody can sequence from hybridoma cells or purified antibody protein, rapidly reformat antibodies, and recombinantly produce antibodies at milligram-to-gram scales. Antibody engineering services include species and isotype switching, humanization, and developing antibody fragments, Fc fusion proteins and multispecific antibodies. Learn more.

Whitepapers

Guide to Recombinant Antibody Engineering
9 Questions to Consider Before Your Next Antibody Engineering Project
How Switching Antibody Isotypes and Fc Regions

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