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MCE Bioactive Compound Libraries
MedChem Express (MCE) One-Stop Compound Screening Platform supplies more than 200 screening libraries and a variety of compounds and phenotypic screening service.
1 December 2022
Figure 2: Physicochemical Properties of 50K Diversity Library
MedChem Express Diversity Compound Libraries are available
MCE provides 50K Diversity Library (HY-L901) and 5K Scaffold Library (HY-L902), which are the most suitable starting libraries for phenotypic and target-based HTS to drive your chemistry screening project.
50K Diversity Library (HY-L901) ↗
A representative diversity set.
The perfect balance of library size and compound diversity!
5K Scaffold Library (HY-L902) ↗
Each compound represents one unique scaffold.
One of the most cost-effective libraries.
Figure 1: Comparison of tanimoto coefficient between E brand and MCE: ranges from 0 to +1 (where +1 is the highest similarity)
High diversity
50K Diversity Library
- 50,000 compounds, 36,857 unique scaffolds (Bemis-Murcko)
- Each scaffold 1 to 7 compounds
- Average tanimoto coeffificient of 0.508
5K Scaffold Library
- 5,000 compounds, 5,000 unique scaffolds (Bemis-Murcko)
- Average tanimoto coeffificient of 0.28
- Maximum structural diversity
High hit probability
- All the compounds are drug-like, conforming to “Lipinski’s Rule of Five”
High reliability
- PAINS motifs or other inappropriate chemical structures removed
- NMR and HPLC validated to ensure high quality and purity (≥90%)
Convenient and time-saving
- Pre-plates of 10 mM in DMSO solutions
