15 June 2023

Preclinical research proteins with enhanced activity & stability

AdipoGen Life Sciences produces an innovative panel of recombinant proteins in mammalian cells for numerous research fields, including cell therapy, preclinical and immuno-oncology research.

The development of recombinant proteins is performed using different production expression systems, including the mammalian cell lines CHO and HEK 293. The mammalian cell lines allow AdipoGen Life Sciences to produce exogenous recombinant proteins secreted into the cell medium with post-translational modifications and glycosylations closer to endogenous proteins compared to productions in E. coli. However, for some difficult-to-produce in mammalian cells proteins, we also use bacteria (E. coli) and/or insect cells as a host. AdipoGen Life Sciences’ first goal is to provide high purity, low endotoxin and biologically active recombinant proteins, leveraging its in-house protein technologies.

Recombinant proteins are used throughout the life science academia and industry in a plethora of applications. They elicit their mechanism of action by activating signaling pathways through binding to specific cell-surface receptors. Their use ranges from cell culture to bioprocessing and advanced cell and gene therapy. A defined composition of the cell culture medium to guarantee batch-to-batch reproducibility has become inevitable. The development of animal-component-free recombinant proteins eliminates the risk of contamination that has been associated with animal and human serum-derived media.

TNF ligands multimeric proteins

CD40L (human) (multimeric) (rec.) (AG-40B-0010)
CD40L (human) (multimeric) (rec.) (Certified Serum Grade) (AG-40B-0010CSG)
CD40L (mouse) (multimeric) (rec.) (AG-40B-0020)
FasL (human) (multimeric) (rec.) (AG-40B-0130)
TNF-α (human) (multimeric) (rec.) (AG-40B-0019)

COMP proteins

COMP (rat):Angiopoietin-1 (human) (rec.) (AG-40B-0147)
VISTA (mouse):COMP (mouse) (rec.) (His) (AG-40B-0181)
VISTA (human):COMP (mouse) (rec.) (His) (AG-40B-0183)

Monomeric proteins fused to Fc (KIH-technology)

IL-2 (human) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0224)
IL-2 (mouse) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0225)
IL-2 Superkine (monomeric):Fc-KIH (human) (rec.) (AG-40B-0222)
IL-2 Superkine H9T (monomeric):Fc-KIH (human) (rec.) (AG-40B-0223)
IL-2 (human) (Switch-2) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0234)
IL-7 (human) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0238)
IL-12 (mouse):Fc-KIH (human) (rec.) (AG-40B-0240)
IL-23 (mouse):Fc-KIH (human) (rec.) (AG-40B-0235)
IL-27 (mouse):Fc-KIH (human) (rec.) (AG-40B-0236)
IL-33 (oxidation resistant) (human) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0233)
IL-38 (aa 1-152) (human) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0241)
IL-38 (aa 20-152) (human) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0226)
IL-38 (aa 3-152) (mouse) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0227)
IL-37 (human) (monomeric):Fc-KIH (human) (rec.) (AG-40B-0221)
Fc-KIH (human) IgG1 Control (rec.) (AG-35B-0015)

Fc-fusion proteins (wild-type or non-lytic)

LAG-3 (human):Fc (human) (rec.) (AG-40B-0031)
LAG-3 (mouse):Fc (mouse) (rec.) (AG-40B-0039)
CTLA-4 (human):Fc (human) (rec.) (non-lytic) (CHI-HF-220A4)
CTLA-4 (mouse):Fc (mouse) (rec.) (non-lytic) (CHI-MF-120A4)
IL-21 (mouse):Fc (mouse) (rec.) (non-lytic) (CHI-MF-12021)
IL-35 (human):Fc (human) (rec.) (CHI-HF-21035)
IL-35 (mouse):Fc (human) (rec.) (CHI-MF-11135)
Jagged-1 (mouse):Fc (human) (rec.) (AG-40A-0157T)
VSTM5 (human):Fc (human) (rec.) (non-lytic) (AG-40B-0237)
VSTM5 (mouse):Fc (mouse) (rec.) (non-lytic) (AG-40B-0239)

Proteins with site-directed mutations

DLL4 (human):Fc (human) (rec.) (highly active mutant) (AG-40B-0176)
IL-2 Superkine (Fc) (AG-40B-0111)
IL-2 Superkine (Fc) (H9T) (AG-40B-0219)
IL-15 (mutant) (human):Fc (human) (rec.) (CHI-HF-21015M)
IL-33 (oxidation resistant) (human) (rec.) (untagged) (AG-40B-0160)
TGFβ1 (mutant) (human):Fc (human) (rec.) (CHI-HF-210TGFBM)

Selected other specialty proteins

BAFF, Soluble (human) (60-mer) (rec.) (highly active) (AG-40B-0112)
CD152 [CTLA-4] (human) (rec.) (untagged) (AG-40B-0232)
Irisin (rec.) (untagged) (E. coli) (AG-40B-0103)
Progranulin (human) (rec.) (untagged) (AG-40A-0188Y)

For more information visit AdipoGen Life Sciences’ landing page proteins with enhanced activity and stability.

Preclinical research proteins with enhanced activity & stability

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