Supplier of leading edge proteins for biomedical and immunology research
Chimerigen Laboratories develops and manufactures high quality and leading edge proteins for biomedical and immunology research. One of their specialties is the production of unique immunoglobulin based chimeric fusion proteins using advanced cellular and molecular biological techniques. These reagents are used successfully in basic and applied research. Because of the high performance characteristics and quality the Chimerigen fusion proteins are widely recognized reagents and are cited in many scientific publications.
Bio-Connect Life Sciences supplies all Chimerigen Laboratories proteins in the Benelux. If you have any questions, please contact the helpdesk.
Major product lines from Chimerigen Laboratories
- Immunoglobulin based chimeric fusion proteins
- Proteins (low endotoxin for in vivo animal research)
Immune Checkpoint Proteins – The B7-CD28 Superfamily
The B7 family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. Activation of T and B lymphocytes is initiated by engagement of cell-surface, antigen-specific T cell or B cell receptors, but additional signals delivered simultaneously by B7 ligands determine the ultimate immune response. These “costimulatory” or “coinhibitory” signals are delivered by B7 ligands through the CD28 family of receptors on lymphocytes, resulting also in the modulation of interleukin production. Interaction of B7-family members with costimulatory receptors augments immune responses and interaction with coinhibitory receptors attenuates immune responses.
There are currently nine known members of the B7 family: B7.1 (CD80), B7.2 (CD86), inducible costimulator ligand (ICOS-L), programmed death-1 ligand (PD-L1), programmed death-2 ligand (PD-L2), B7-H3, B7-H4, VISTA (B7-H5) and B7-H7, and four known members of the CD28 family: CD28, CTLA-4 (CD152), ICOS, PD-1. The importance of the B7-CD28 superfamily in regulating immune responses is shown by the role of some members in the development of immunodeficiency and autoimmune diseases. Manipulation of the signals delivered by B7 ligands has shown potential in the treatment of autoimmunity, inflammatory diseases and cancer.
|CD28 (huCD28 (human):Fc (human) (rec.) (CHI-HF-210CD28)|
|CD152 [CTLA-4] (human):Fc (human) (rec.) (CHI-HF-210A4)|
|CD152 [CTLA-4] (mouse):Fc (mouse) (rec.) (CHI-MF-110A4)|
|CD278 [ICOS] (human):Fc (human) (rec.) (CHI-HF-210ICOS)|
|CD279 [PD-1] (human):Fc (human) (rec.) (CHI-HF-210PD1)|
|CD80 (human):Fc (human) (rec.) (CHI-HF-210CD80)|
|CD273 [PD-L2] (human):Fc (human) (rec.) (CHI-HF-210PDL2)|
|CD274 [B7-H1/PD-L1] (human) (rec.) (CHI-HF-200PDL1)|
|CD275 [B7-H2] (human):Fc (human) (rec.) (CHI-HF-210B7H2)|
|B7-H3(4Ig) [B7-H3b] (human) (rec.) (His) (CHI-HF-201B7H3B)|