COVID-19 Reagents

The ongoing pandemic of the newly identified COVID-19 has been declared a public health emergency of international concern by the WHO. Several of our suppliers offer products to assist the research related to this virus.

The causative SARS-CoV-2 virus attaches to cells by binding its outer “Spike” proteins to a receptor protein called ACE2 (angiotensin-converting enzyme 2) that is highly expressed on respiratory cells. ACE2 also acts as the receptor for the human respiratory coronavirus NL63 and the SARS-coronavirus (SARS-CoV). Studies have shown that the binding affinity of the virus Spike protein for ACE2 correlates with higher transmissibility of the coronavirus and contagiousness of the disease. Angiotensin receptor blockers have been proposed as tentative SARS-CoV-2 therapeutics. Interestingly, ACE2 activity may also have a protective effect against virus-induced lung injury by increasing the production of the vasodilator angiotensin 1–7. [ref. 1-5]

Click on the logos and go directly to the products.

- Antibodies - Proteins - ELISA kits/pair set - cDNA/Genes	- Antibodies - Peptides - Proteins	- Disinfection tools - Antibodies	- Antiviral agents - Compound library
- Antibodies - Antigens	- 1-step RT-qPCR reagents	- Antibodies - Proteins	- Proteins
- Antibodies - Proteins	- Assay kit - Proteins	- Rapid tests	- Antibodies - Antiviral agent - PCR detection kit - Recombinant proteins
- 1-step RT-qPCR reagents - Viral transport system - Viral DNA/RNA isolation kit - Recombinant antigens	- Antibodies - Recombinant antigens	- Recombinant proteins - Peptide fragment	- Viral transport medium
- Antibodies - Proteins	- Diagnostics tests	- Rapid test - Assay kit	- Virus RNA prep kit - Testkit - Mastermixes - Raw materials
- Antibodies - Proteins - ELISA kits - PCR kits	- Inhibitors - Compound library
If you want to order, please send your request to: orders(at)bio-connect.nl

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COVID-19 strategies

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COVID-19 relevant tools by Sino Biological

Sino Biological successfully expressed COVID-19 spike proteins to develop therapies or further research the virus. This new virus belongs to the Betacoronavirus Genus, which also includes SARS CoV (2003) and MERS CoV (2012). The sequence reveals that COVID-19 is more similar to SARS-CoV (70% similarity) than to MERS-CoV (40%). Same as all other coronaviruses, the genome of COVID-19 encodes the spike protein, the envelope protein, the membrane protein, and the nucleocapsid protein.

Antibodies

Proteins

ELISA kits/pair set

cDNA/Genes

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ABclonal's SARS-CoV-2 related products

ABclonal has several SARS-CoV-2 related products available. If you want to order, please send your request to: orders(at)bio-connect.nl

Cat. No.	Product Name	Description
43903	Viral Transport System	The Beaver Viral Transport System enables clinical specimens containing viruses, including SARS-CoV-2, chlamydia, mycoplasma, ureaplasma, to be collected, transported and stored at room temperature for up to one week before DNA/RNA isolation. The 43903 can be used in throat swabs and nasal swabs.
70406	Viral DNA/RNA Isolation Kit	BeaverBeadsTM Viral DNA/RNA Isolation Kit allows manual and automated extraction of DNA and RNA from viruses in cell-free samples, such as serum and plasma. The extraction process utilizes superparamagnetic microspheres without centrifugation. Extracted products can be used for digestion, PCR amplification, detection and other follow-up experiments.
RK20407	ABScript II One Step RT-qPCR Probe Kit	ABScript II One Step RT-qPCR Probe Kit a ready-to-use kit allowing reverse transcription and subsequent probe-based qPCR in a single tube. It contains all components for RT-qPCR except primers, probes and RNA templates. The one-step format significantly improves sensitivity and effectively prevent contamination. The ABScript II Reverse Transcriptase in the kit provides reliable reverse transcription to a wide range of RNA template amount. After reverse transcription, the Hot-start version of Taq polymerase is activated at 95°C and the ABScript II Reverse Transcriptase is inactivated simultaneously. In the sequential PCR reaction, the 5 '-3 'exonuclease activity of Taq polymerase cleaves the hybridized probe, separating the reporter from the quencher and releasing fluorescent signal. The ABScript II One Step RT-qPCR Probe Kit is an ideal product for high-speed analyses of low input RNA sample.

SARS-CoV-2 Recombinant Antigens

SARS-CoV-2 Antigens	Gene	Expression host
S1-RBD-C-6His	Spike	Human cells
S1-RBD-TEVs-hFc-C-6His	Spike	Human cells
S1-C-6His	Spike	Human cells
S1-TEVs-hFc-C-6His	Spike	Human cells
S2-ECD-C-6His	Spike	Human cells
S1+S2-ECD-C-6His	Spike	Human cells
N-6His	Nucleocapsid	E.coli cells

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COVID-19 antibodies and reagents from MP Biomedicals

MP Biomedicals offers three monoclonal antibodies from mouse with high affinity to the SARS-CoV-2 spike proteins for use in various applications, including western blot, immunoprecipitation, ELISA tests, rapid tests and flow cytometry. They also added five recombinant antigens for SARS-CoV-2 diagnostics and research applications to their portfolio.
If you want to order, please send your request to: orders(at)bio-connect.nl

Antibodies

Cat. No.	Description	Host	Clonality	Applications	Amount
08720301	Anti-coronavirus (SARS-CoV-2) spike S1, mouse, mAb	Mouse	Monoclonal	WB, ELISA, IP, FACS	50 ug
08720302	Anti-coronavirus (SARS-CoV-2) spike S1, mouse, mAb	Mouse	Monoclonal	WB, ELISA, IP, FACS	250 ug
08720401	Anti-coronavirus (SARS-CoV-2) spike S2, mouse, mAb	Mouse	Monoclonal	WB, ELISA, IP, FACS	50 ug
08720402	Anti-coronavirus (SARS-CoV-2) spike S2, mouse, mAb	Mouse	Monoclonal	WB, ELISA, IP, FACS	250 ug
08720411	Anti-coronavirus (SARS-CoV-2) (B) spike S2, mouse, mAb	Mouse	Monoclonal	WB, ELISA, IP, FACS	50 ug
08720412	Anti-coronavirus (SARS-CoV-2) (B) spike S2, mouse, mAb	Mouse	Monoclonal	WB, ELISA, IP, FACS	250 ug

Recombinant antigens

Cat. No	Description	Expressed Host	Species	Amount
08720501	SARS-CoV-2 Nucleocapsid Protein, His tag (E. coli)	E. coli	SARS-CoV-2	250 ug
08720502	SARS-CoV-2 Nucleocapsid Protein, His tag (E. coli)	E. coli	SARS-CoV-2	1 mg
08720511	SARS-CoV-2 Nucleocapsid Protein, His tag (HEK293 cells)	HEK293 cells	SARS-CoV-2	25 ug
08720512	SARS-CoV-2 Nucleocapsid Protein, His tag (HEK293 cells)	HEK293 cells	SARS-CoV-2	100 ug
08720421	SARS-CoV-2 Spike Protein (S1+S2), His tag (HEK293 cells)	HEK293 cells	SARS-CoV-2	25 ug
08720422	SARS-CoV-2 Spike Protein (S1+S2), His tag (HEK293 cells)	HEK293 cells	SARS-CoV-2	100 ug
08720601	ACE2, His tag (E. coli)	E. coli	Human	250 ug
08720602	ACE2, His tag (E. coli)	E. coli	Human	1 mg
08720611	ACE2, His tag (HEK293 cells)	HEK293 cells	Human	25 ug
08720612	ACE2, His tag (HEK293 cells)	HEK293 cells	Human	100 ug

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COVID-19 products from Peptides International

Cat. No	Description
SARS-011	Novel Coronavirus 2019-nCoV Spike Glycoprotein-S1, Recombinant
SARS-012	Novel Coronavirus 2019-nCoV Spike Glycoprotein-S2, Recombinant
SARS-013	Coronavirus 2019 Nucleocapsid Recombinant
SARS-014	Coronavirus 2019 Spike E-Mosaic Recombinant
SARS-015	Coronavirus 2019 Nucleocapsid Mosaic Recombinant
BP12-331	Putative orf1ab Polyprotein (3233-3247) [SARS coronavirus]

Related products

Cat. No.	Description
PAN-4332	Angiotensin (Human, 1-7)
PAN-4001	Angiotensin II (Human)
PBK-4002	Bradykinin (Human, Bovine, Rat, Mouse)
IEC-4320-v	E-64-c
IED-4321-v	E-64-d
BP10-400-NEP	FLAG peptide, H-DYKDDDDK-OH
BP11-325-NEP	3X FLAG Peptide
HAP-70000-PI	HA Peptide
PMI-3843-PI	Influenza Matrix Protein M1 (58-66)
POV-3659-PI	OVA Peptide (257-264)
BP12-331-NEP	Putative orf1ab Polyprotein (3233-3247) [SARS coronavirus]
SARS-251	SARS-Associated Coronavirus Matrix Recombinant
SARS-252	SARS-Associated Coronavirus Matrix Recombinant
SARS-253	SARS Nucleocapsid (1-49)
SARS-254	SARS Core (340-390)
SARS-255	SARS Core (1-49,192-220 a.a.)
SARS-256	SARS-Associated Coronavirus Spike Mosaic S (M) Recombinant
SARS-257	SARS-Associated Coronavirus Spike Mosaic S(C) Recombinant
SARS-258	SARS-Associated Coronavirus Spike Mosaic S (N) Recombinant

If you want to order, please send your request to: orders(at)bio-connect.nl

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Viral Transport Media by Life Science Group

Life Science Group has announced that they are now manufacturing Viral Transport Medium to both CDC and WHO protocols.

The constituents of suitable viral transport media are designed to provide an isotonic solution containing protective protein, antibiotics to control microbial contamination, and one or more buffers to control the pH.

Liquid transport media are used primarily for transporting swabs or materials released into the medium from a collection swab. Liquid media may be added to the specimens when inactivation of the viral agent is likely and when the resultant dilution is acceptable.

This Viral Transport Medium (CDC) is manufactured to current Center for Disease Control and Prevention (CDC) protocol SOP SOP#: DSR-052-01

Formulation
Foetal Bovine Serum (FBS)
Hanks Balanced Salt Solution (HBSS) 1X with calcium and magnesium
ions, no phenol red
Gentamicin sulfate (50mg/mL)
Amphotericin B (250ug/mL) (Fungizone)

If you want to order, please send your request to: orders(at)bio-connect.nl

Cat. No.	Description	Amount
VTA-001A	Viral Transport Medium CDC Protocol	500 ml
VTA-001U	Viral Transport Medium CDC Protocol	3 ml

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Arigo's SARS-CoV-2 products

Arigo Biolaboratories just released the anti-SARS-CoV / SARS-CoV-2 nucleocapsid protein antibody (ARG66735), which has a cross-reactivity with SARS-CoV-2 nucleocapsid protein. Especially, this antibody is a recombinant human monoclonal antibody with high affinity against SARS-CoV-2 NP protein. If you want to order, please send your request to: orders(at)bio-connect.nl

Cat. No.	Description	Tested Reactivity	Tested Application
ARG66735	anti-SARS-CoV / SARS-CoV-2 nucleocapsid protein antibody	Virus	ELISA, ICC/IF, WB
ARG23887	Goat anti-Human IgG antibody (HRP), pre-adsorbed	Human	Depletion, ELISA, ICC, IHC-P, WB
ARG20568	Goat anti-Human IgG antibody (FITC), pre-adsorbed	Human	FACS, ICC/IF, IHC-Fr, IHC-P, WB
ARG21905	Goat anti-Human IgG antibody (Biotin), pre-adsorbed	Human	Depletion, ELISA, FACS, ICC, IHC-P, WB
SARS-CoV-2 recombinant proteins
ARG70217	SARS-CoV-2 nucleocapsid recombinant protein	Virus	SDS-PAGE
ARG70216	SARS-CoV-2 nucleocapsid recombinant protein	Virus	SDS-PAGE
ARG70218	SARS-CoV-2 Spike recombinant protein (S1 Subunit)	Virus	SDS-PAGE
ARG70219	SARS-CoV-2 Spike recombinant protein (RBD)	Virus	SDS-PAGE
Antibodies cross-react with SARS-CoV-2
ARG11092	SARS-CoV Spike protein antibody [1A9]	Virus	FACS, FuncSt, WB
ARG11096	SARS-CoV ORF7a antibody [3C9]	Virus	ICC/IF, WB
Antibodies against SARS-CoV
ARG54886	SARS-CoV Spike protein antibody	Virus	WB
ARG54884	SARS-CoV M protein antibody	Virus	ELISA
ARG11095	SARS-CoV NSP8 antibody [5A10]	Virus	ICC/IF, WB
ARG54885	SARS-CoV Spike protein antibody	Virus	WB
ARG11091	SARS-CoV nucleocapsid protein antibody [6H3]	Virus	ICC/IF, WB
ARG11093	SARS-CoV RdRp R2 antibody [4E6]	Virus	WB
Antibodies for studying viral infection
ARG41099	anti-ACE2 antibody	Human, Mouse, Rat	IHC-P, IP, WB
ARG54925	anti-DDX58 / RIGI antibody	Human, Mouse, Rat	ELISA, ICC/IF, IHC, WB
ARG64555	anti-LGP2 antibody	Human	WB
ARG64661	anti-TMPRSS2 antibody	Human	WB
ARG55413	anti-IFIH1 / MDA5 antibody	Human, Mouse	ICC/IF, IHC-P, WB
ARG66717	anti-MAVS antibody	Human	IP, WB
Related recombinant proteins
ARG70213	HCoV-NL63 nucleocapsid recombinant protein	Virus	SDS-PAGE
ARG70214	MERS-CoV nucleocapsid recombinant protein	Virus	SDS-PAGE
ARG70215	SARS-CoV nucleocapsid recombinant protein	Virus	SDS-PAGE

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Validated COVID-19 testkit and virus RNA prep kit

Jena Bioscience can now offer viral RNA+DNA preparation kit, an complete validated COVID-19 test kit and mastermixes and raw materials for development of COVID-19 test.

Cat. No.	Product Name	Description	Amount
PP-223S	Viral RNA+DNA Preparation Kit	Viral RNA+DNA Preparation Kit is designed for rapid and effective isolation of RNA and DNA from a variety of pathogen organisms such as virus or bacteria. Samples can be fresh or frozen plasma/blood (treated with anticoagulants excepted heparin), serum, other cell-free body fluids or pathogen-infected tissue. The Kit is specifically designed to isolate high-quality nucleic acids using low elution volumes and allowing sensitive downstream analysis including quantitative PCR and RT-PCR. The purified RNA/DNA is free of proteins and nucleases. Viral RNA+DNA Preparation Kit uses lysis buffer including chaotropic salts to inactivate RNases/DNases and advanced silica-gel membrane technology for fast purification of intact RNA/DNA. The preparation procedure is optimized to give reproducible results within 30 min.	50 preparations
PCR-703	1copy™ COVID-19 qPCR Kit CE IVD	CE IVD test for clinical diagnosis of Coronavirus (COVID-19). Test results in less than 90 min. Samples from swabs, sputum, blood, stool, urine. E/RdRP genes based testing according to WHO reference. For research use only! Not intended for human or animal diagnostic or therapeutic uses.	100 tests
Mastermixes and raw materials for COVID-19 testassay
PCR-512XS	SCRIPT One-Step RT-qPCR ProbesMaster	SCRIPT One-Step RT-qPCR ProbesMaster is designed for quantitative real-time analyses of RNA templates using Dual Labeled Fluorescent Probes.	500 ul
PCR-513XS	SCRIPT One-Step RT-qPCR ProbesMaster highROX	SCRIPT One-Step RT-qPCR ProbesMaster with highROX is designed for quantitative real-time analyses of RNA templates using Dual Labeled Fluorescent Probes.	500 ul
PCR-516XS	SCRIPT One-Step RT-qPCR ProbesMaster lowROX	SCRIPT One-Step RT-qPCR ProbesMaster with lowROX is designed for quantitative real-time analyses of RNA templates using Dual Labeled Fluorescent Probes.	500 ul
PCR-505S	SCRIPT Reverse Transcriptase	SCRIPT Reverse Transcriptase is a genetically engineered version of M-MLV Reverse Transcriptase (M-MLV RT) with eliminated RNase H activity and increased thermal stability.	20.000 units
NU-1023S	dNTP Mix - 25 mM Solution	dNTP Mix is an equimolar mixture of ultrapure dATP, dCTP, dGTP, and dTTP supplied as clear aqueous solution (pH 8.5).	200 ul
NU-1005S	dNTP Bundle	dNTP Bundle contains four separate solutions of ultrapure dATP, dCTP, dGTP and dTTP supplied as clear aqueous solutions (pH 8.5).	4 x 200 ul
NU-1001L	dATP - Solution	dATP, PCR-grade is supplied as ultrapure aqueous solution (pH 8.5) and suitable for all molecular biology applications including PCR/qPCR, reverse transcription, DNA labeling and DNA sequencing.	1 ml
NU-1002L	dCTP - Solution	dCTP, PCR-grade is supplied as ultrapure aqueous solution (pH 8.5) and suitable for all molecular biology applications including PCR/qPCR, reverse transcription, DNA labeling and DNA sequencing.	1 ml
NU-1003L	dGTP - Solution	dGTP, PCR-grade is supplied as ultrapure aqueous solution (pH 8.5) and suitable for all molecular biology applications including PCR/qPCR, reverse transcription, DNA labeling and DNA sequencing.	1 ml
NU-1004L	dTTP - Solution	dTTP, PCR-grade is supplied as ultrapure aqueous solution (pH 8.5) and suitable for all molecular biology applications including PCR/qPCR, reverse transcription, DNA labeling and DNA sequencing.	1 ml
NU-1007L	dITP - Solution	dITP, PCR-grade is supplied as ultrapure aqueous solution (pH 8.5) and suitable for all molecular biology applications including PCR/qPCR, reverse transcription, DNA labeling and DNA sequencing.	1 ml
NU-1008L	dUTP - Solution	dTTP, PCR-grade is supplied as ultrapure aqueous solution (pH 8.5) and suitable for all molecular biology applications including PCR/qPCR, reverse transcription, DNA labeling and DNA sequencing.	1 ml

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COVID-19 products by MyBioSource

MyBioSource offers a comprehensive portfolio of SARS-CoV-2/COVID-19 coronavirus and related products. If you want to order, please send your request to: orders(at)bio-connect.nl

Cat. No.	Description	Host	Clonality	Application
Antibodies
MBS355890	Anti-SARS-CoV-2 S1 / COVID-19, Humanized antibody (Detection Ab)	Cultured in vitro	Monoclonal	ELISA, LFA
MBS8574749	2019-NCOV antibody-CR3022 (IgG)	ExpiCHO - S
MBS8574747	Anti 2019-nCov Spike Protein S2 Domain mAb	Homo; 293 cell expressed	Monoclonal	SDS-PAGE
MBS434251	Anti-NP Protein (SARS-CoV-2) Polyclonal Antibody	Rabbit	Polyclonal	WB, ELISA
MBS434247	Anti-RBD Domain (SARS-CoV-2 Spike) Monoclonal Antibody	Mouse	Monoclonal	WB, ELISA
MBS355887	Anti-SARS-CoV-2 Nucleocapsid / COVID-19, Humanized antibody	Cultured in vitro	Monoclonal	ELISA, LFA
MBS355888	Anti-SARS-CoV-2 Nucleocapsid / COVID-19, Humanized antibody	Cultured in vitro	Monoclonal	ELISA, LFA
MBS355889	Anti-SARS-CoV-2 S1 / COVID-19, Humanized antibody (Capture Ab)	Cultured in vitro	Monoclonal	ELISA, LFA
MBS355893	Anti-SARS-CoV-2 Spike RBD IgG, Humanized antibody (Positive Control)	Cultured in vitro	Monoclonal	LFA
MBS355896	Anti-SARS-CoV-2 Spike RBD IgG/IgM, Humanized antibody (Positive Control)	Cultured in vitro	Monoclonal	LFA
MBS434243	Anti-Spike Protein (SARS-CoV-2) Polyclonal Antibody	Rabbit	Polyclonal	WB, ELISA
MBS569937	Coronavirus (COVID-19 & SARS-CoV NP) Antibody	Mouse	Monoclonal	ELISA, IF
MBS569938	Coronavirus (COVID-19 & SARS-CoV NP) Antibody	Mouse	Monoclonal	ELISA, IF
MBS569939	Coronavirus (COVID-19 & SARS-CoV NP) Antibody	Mouse	Monoclonal	ELISA, IF
MBS569940	Coronavirus (COVID-19 & SARS-CoV NP) Antibody	Mouse	Monoclonal	ELISA, WB, IF
MBS569961	Coronavirus (COVID-19 NP) Antibody	Mouse	Monoclonal	ELISA
MBS569951	Coronavirus (COVID-19) Antibody	Mouse	Monoclonal	ELISA
MBS669375	Coronavirus (COVID-19) Nucleocapsid Antibody		Polyclonal
MBS669373	Coronavirus (COVID-19) Spike Antibody		Polyclonal
MBS669372	Coronavirus (COVID-19) Spike Antibody (Clone: ABM19C9)		Monoclonal
MBS669374	Coronavirus (COVID-19) Spike Protein Antibody		Polyclonal
MBS8574744	Human anti-2019-nCoV N mAb (BN18)		Monoclonal	ELISA
MBS8574743	Human anti-2019-nCoV N mAb (BN9)		Monoclonal	ELISA
MBS8574746	human anti-2019-nCoV S1 mAb (S1a)	Humanized	Monoclonal	ELISA
MBS8574748	Human anti-2019-nCoV S2 mAb (S2a)
MBS8574745	human anti-2019-nCoV Spike S1 mAb (S1)	Humanized	Monoclonal	ELISA
MBS154639	SARS-CoV-2 (COVID-19) Nucleoprotein	Mouse		ELISA, IF, WB
MBS154640	SARS-CoV-2 (COVID-19) Nucleoprotein	Mouse		ELISA, IF, WB
MBS154641	SARS-CoV-2 (COVID-19) Nucleoprotein	Mouse		ELISA, IF
MBS154642	SARS-CoV-2 (COVID-19) Nucleoprotein	Mouse		ELISA, IF
MBS154643	SARS-CoV-2 (COVID-19) Nucleoprotein	Mouse		ELISA, IF
MBS150849	SARS-CoV-2 (COVID-19, 2019-nCoV) Envelope antibody	Rabbit	Polyclonal	ELISA
MBS150780	SARS-CoV-2 (COVID-19, 2019-nCoV) Spike Antibody	Rabbit	Polyclonal	ELISA
MBS378285	SARS-CoV-2 (COVID-19, 2019-nCoV) Spike Protein S1+S2 Extracellular Domain Antibody	Chicken	Polyclonal	ELISA
Proteins
MBS553718	2019 nCoV/COVID19 Nucleocapsid Recombinant	CHO Cells
MBS553719	2019 nCoV/COVID19 RBD Recombinant	CHO Cells
MBS553720	2019 nCoV/COVID19 RBD Recombinant, Biotinylated	CHO Cells
MBS553721	2019 nCoV/COVID19 Spike protein S Recombinant	CHO Cells
MBS553722	2019 nCoV/COVID19 Spike protein S1 Recombinant	CHO Cells
MBS553723	2019 nCoV/COVID19 Spike protein S1 Recombinant, Biotinylated	CHO Cells
MBS8574751	2019-nCoV (COVID19) Spike protein RBD	HEK193 Cells
MBS8574737	2019-nCoV 3CL MPro Recombinant Protein
MBS8574736	2019-nCoV E protein; 2019-nCoV sM protein
MBS8574735	2019-nCoV M Recombinant Protein
MBS8574733	2019-nCoV N protein C-ter Recombinant Protein (N3)-AP fusion
MBS8574727	2019-nCoV N Recombinant Protein (Mutated)
MBS8574734	2019-nCov Nucleocapsid protein N fragment protein (NX)	E Coli		SDS-PAGE
MBS8574726	2019-nCov Nucleocapsid Recombinant Protein (full length)	E Coli		ELISA
MBS8574729	2019-nCov Nucleocapsid Recombinant Protein N1 fragment (N-ter domain)	E Coli		ELISA
MBS8574730	2019-nCov Nucleocapsid Recombinant Protein N2 fragment (N-ter domain)	E Coli		ELISA
MBS8574728	2019-nCov Nucleocapsid Recombinant Protein N3 fragment (C-ter domain)	E Coli		ELISA
MBS8574731	2019-nCov Nucleocapsid Recombinant Protein N4 fragment (N-ter partially truncated)	E Coli		SDS-PAGE
MBS8574732	2019-nCov Nucleocapsid Recombinant Protein N5 fragment (N-ter partially truncated)	E Coli		SDS-PAGE
MBS8574723	2019-nCoV S1-Fc Recombinant Protein			Immunogen, calibrator or standard
MBS8574722	2019-nCoV S1-his Recombinant Protein
MBS8574724	2019-nCov Spike Protein RBD Domain	HEK293F		SDS-PAGE
MBS569941	Coronavirus (COVID-19 NP; 1-430) Antigen, Recombinant >90%	E Coli		LFA
MBS569942	Coronavirus (COVID-19 NP; 1-430) Antigen, Recombinant >90%	E Coli		LFA
MBS569943	Coronavirus (COVID-19 NP; 1-430) Antigen, Recombinant >90%	E Coli		ELISA
MBS569944	Coronavirus (COVID-19 NP; 1-430) Antigen, Recombinant >90%	E Coli		ELISA
MBS569945	Coronavirus (COVID-19 Spike Protein RBD) Antigen, Recombinant >95%	Mammalian Cell		Control
MBS569946	Coronavirus (COVID-19 Spike Protein RBD; 331-524) Antigen, Recombinant >95%	Mammalian Cell		Control, ELISA, LFA
MBS569947	Coronavirus (COVID-19 Spike Protein S1 S2 ECD) Antigen, Recombinant >90%	Insect Cell		Control
MBS569948	Coronavirus (COVID-19 Spike Protein S1) Antigen, Recombinant >90%	Mammalian Cell		Control
MBS569949	Coronavirus (COVID-19 Spike Protein S1) Antigen, Recombinant >95%	Mammalian Cell		Control, ELISA, LFA
MBS569950	Coronavirus (COVID-19 Spike Protein; Full Length) Antigen, Recombinant >90%	E Coli		Control
MBS669371	COVD-19 Spike Glycoprotein-S2	HEK293
MBS596190	Covid-19 (coronavirus)Nucleocapsid (full length) Recombinant Protein	E Coli
MBS569934	COVID-19 Nucelocapsid (N; 2-419aa) Antigen, Recombinant	E Coli
MBS7135899	COVID-19 Nucleocapsid (N; 1-419aa: Full Length), Recombinant	E Coli or Yeast or Baculovirus or Mammalian Cell
MBS669367	COVID-19 Nucleocapsid Mosaic Protein	E Coli
MBS669369	COVID-19 Nucleocapsid Protein	E Coli
MBS398001	COVID-19 Nucleocapsid protein (NP)	E Coli
MBS7135898	COVID-19 Spike (S1; 16-685aa), Recombinant	E Coli or Yeast or Baculovirus or Mammalian Cell
MBS569935	COVID-19 Spike (S1; 1-674aa) Antigen, Recombinant	Mammalian Cell Expression System
MBS569936	COVID-19 Spike (S2; 685-1211aa) Antigen, Recombinant	Mammalian Cell Expression System
MBS669368	COVID-19 Spike E-Mosaic Protein	E Coli
MBS669370	COVID-19 Spike Glycoprotein-S1	HEK293
MBS398003	COVID-19 Spike Protein S1 Receptor-Binding Domain (S1RBD)	E Coli
MBS8574742	Nucleocapsid Protein-His
MBS8574750	Recombinant 2019-nCoV S1 Protein	Human Cells
MBS8574752	Recombinant 2019-nCoV S1 Protein RBD-SD1 (C-6His)	Human Cells		Immunogen, calibrator or standard
MBS8574725	Recombinant 2019-nCoV S2 Protein (C-Fc)	Human Cells		Immunogen, calibrator or standard
MBS8574721	Recombinant 2019-nCoV Spike Protein (C-6His)	Human Cells		Immunogen, calibrator or standard
MBS485211	Recombinant Coronavirus-19 Spike (1000–1200aa) protein	E Coli		ELISA, WB
MBS485210	Recombinant Coronavirus-19 Spike (800–1000aa) protein	E Coli		ELISA, WB
MBS8309635	Recombinant COVID-19 3C-like Proteinase	E Coli		ELISA, WB, SDS-PAGE
MBS8309649	Recombinant COVID-19 Envelope Protein	E Coli		ELISA, WB, SDS-PAGE
MBS8309648	Recombinant COVID-19 NP CTD domain	E Coli		ELISA, WB, SDS-PAGE
MBS8309647	Recombinant COVID-19 NP NTD domain	E Coli		ELISA, WB, SDS-PAGE
MBS8309646	Recombinant COVID-19 Nucleocapsid Protein	E Coli		ELISA, WB, SDS-PAGE, MS
MBS8309645	Recombinant COVID-19 S Protein NTD	Human Cells		ELISA, WB, SDS-PAGE
MBS8309636	Recombinant COVID-19 S Protein RBD	Human Cells		ELISA, WB, SDS-PAGE
MBS8309637	Recombinant COVID-19 S Protein RBD	Human Cells		ELISA, WB, SDS-PAGE, MS
MBS8309638	Recombinant COVID-19 S Protein RBD-SD1	Human Cells		ELISA, WB, SDS-PAGE
MBS8309639	Recombinant COVID-19 S Protein RBD-SD1	Human Cells		ELISA, WB, SDS-PAGE
MBS8309640	Recombinant COVID-19 S1 Protein	Human Cells		ELISA, WB, SDS-PAGE
MBS8309641	Recombinant COVID-19 S1 Protein	Human Cells		ELISA, WB, SDS-PAGE
MBS8309642	Recombinant COVID-19 S1 Protein	Human Cells		ELISA, WB, SDS-PAGE
MBS8309643	Recombinant COVID-19 S1 Protein	Human Cells		ELISA, WB, SDS-PAGE
MBS8309644	Recombinant COVID-19 S1 Protein CTD	Human Cells		ELISA, WB, SDS-PAGE
MBS7135911	Recombinant Human Novel Coronavirus Spike Glycoprotein (S), Partial	E Coli or Yeast or Baculovirus or Mammalian Cell
MBS355892	Recombinant SARS-Cov-2 Nucleocapsid Protein	E Coli		LFA
MBS355894	Recombinant SARS-Cov-2 Nucleocapsid Protein	E Coli		LFA
MBS5316490	Recombinant SARS-CoV-2 Nucleocapsid Protein	E Coli		ELISA, LF
MBS355895	Recombinant SARS-Cov-2 Spike RBD Protein	HEK293		LFA
MBS398002	SARS-CoV-2 Nucleocapsid Protein (NP), HRP Conjugated			ELISA, IHC, ICC
MBS8574740	Spike RBD antigen-Fc	Expi293
MBS8574741	Spike RBD antigen-His	Expi293
MBS8574738	Spike S1 Protein-Fc	Expi293
MBS8574739	Spike S1 Protein-His	Expi293
Kits
MBS109704	COVID-19 IgG/IgM Antibody Assay Kit (Immunochromatography)
MBS2563834	COVID-19 IgG/IgM Antibody Assay Kit (Immunochromatography)
MBS355891	COVID-19 IgM/IgG Antibody (SARS-CoV-2) Assay Kit
MBS412761	COVID-19 Microplate
MBS598351	COVID-19 Real Time Multiplex RT-PCR Kit
MBS2614310	General SARS-CoV-2 IgG ELISA Kit
MBS2614312	General SARS-CoV-2 IgG/IgM ELISA Kit
MBS2614311	General SARS-CoV-2 IgM ELISA Kit
MBS398004	Human Anti-COVID-19 Nucleocapsid Protein (NP) IgG ELISA Kit
MBS398005	Human Anti-COVID-19 Spike Protein S1 Receptor-Binding Domain (S1RBD) IgG ELISA Kit
MBS3809906	Human COVID-19 IgG Antibody ELISA Kit
MBS3809905	Human COVID-19 IgG/IgM Antibody ELISA Kit
MBS3809907	Human COVID-19 IgM Antibody ELISA Kit
MBS109703	Novel Cornonvirus (COVID-19) Antigen Detection Kit
MBS2563835	Novel Coronavirus (COVID-19) Nucleic Acid Assay Kit (RT-PCR)
MBS4160442	SARS-CoV-2 (2019-nCoV/Coronavirus) RT-qPCR Rapid Detection Kit
MBS7135927	SARS-CoV-2 IgM IgG Antibody Assay Kit (Immunochromatography)
MBS398006	SARS-CoV-2 NP IgM ELISA Kit
MBS7135926	SARS-CoV-2 Nucleic Acid Dual-Detection Kit (Real-Time PCR Method)
Solution
MBS4160443	COVID-19 Sample Preparation Solution

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Selleck inhibitors and libraries for COVID-19 research

Selleck Chemicals recently released relevant inhibitors and screening libraries for COVID-19-related research.

Cat. No.	Description	CAS No.	Molecular Weight	Molecular Formula
S8932	Remdesivir (GS-5734)	1809249-37-3	602.58	C27H35N6O8P
S7975	Favipiravir (T-705)	259793-96-9	157.1	C5H4FN3O2
S4157	Chloroquine diphosphate	50-63-5	515.86	C18H26ClN3.2H3O4P

These relevant compounds can be found in their screening libraries:

Cat. No.	Description	Basic Information
L7000	Antiviral Compound Library	A unique collection of 348 antiviral compounds used for exploring novel antiviral drug, which is a useful tool for exploring novel antiviral drug. L7000 targets HCV Protease, HIV Protease, Integrase, Reverse Transcriptase, etc.
L7200	Nucleoside Analogue Library	A unique collection of 135 nucleoside analogues used for high throughput screening (HTS) and high content screening (HCS). Nucleoside analogues can be incorporated into DNA and block natural maturation processes. Nucleoside analogues have demonstrated widespread utility as antiviral and anticancer therapeutics.
L1300	FDA-Approved Drug Library	A unique collection of 2682 approved drugs for high throughput screening (HTS) and high content screening (HCS). All drugs were from approved institutions such as FDA,EMA,HMA,CFDA, PMDA,or pharmacopoeia such as USP,BP,EP,JP,Ph.Int,etc., and the bioactivity and safety of the drugs are confirmed by clinical trials. For instant patent approval, L1300 would be the best choice.

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COVID-19 relevant tools by Abnova

Cat. No.	Product Name	Description	Amount
DC0301	COVID-19 Human IgM/IgG Rapid Test	COVID-19 Human IgM/IgG Rapid Test provides a fast, convenient, and qualitative testing of human whole blood, plasma, and serum for COVID-19 IgM and IgG.	20 tests
KA5826	COVID-19 Human IgM IgG Assay Kit	COVID-19 Human IgM IgG Assay Kit is an indirect enzyme-linked immunoassay (ELISA) for qualitative determination of COVID-19 human serum IgM and IgG.	1 Kit
M0022	SpiralPipet™	Abnova’s SpiralPipet™ is a patented spiral-mix, magnetic bead handling system for high throughput precipitation, purification, and extraction. Combining 96 deep well plate with affinity conjugated magnetic beads, SpiralPipet™ easily handles 8 different assays simultaneously by transferring beads from one well to the next for spiral-mixing, binding, washing, and elution reactions via the robotic action of parallel magnetic rods. SpiralPipet™ can also work independently as a stand-alone pipet, allowing greater freedom to expedite your work. SpiralPipet™ simplifies the routine yet labor-intensive process and addresses the needs of rigorous proteomic screening and biomarker discovery applications such as immunoprecipitation(IP, ChIP, RIP), recombinant protein purification, protein-protein interaction, and nucleic acid extraction. SpiralPipet™ delivers reproducible and consistent results by obviating the drawbacks of manual operation. Its integrated on-screen, pipet display allows easy change of parameters tailored to your experiment.	1 Set
KA5519	Viral RNA Purification Kit (Pre-filled)	Viral RNA Purification Kit (Pre-filled) is designed specifically for the optimal automated extraction of RNA from virus on the SpiralPipet™ instrument.	1 Kit
U0383	96 Deep Well Plate (Polypropylene)	96 Deep Well Plate is used for applications with SpiralPipet™ instrument.	50 PCS
U0384	Spin Tip	Spin Tip is used for applications with SpiralPipet™ instrument.	1000 Slides

If you want to order, please send your request to: orders(at)bio-connect.nl

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References

1. ACE2 is the receptor for SARS (SARS-CoV). Li, W. et al., EMBO J (2005)24:1634-1643
2. ACE2 is the receptor for the new virus, SARS-CoV-2. Zhou P, et al. (March 2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin". Nature. 579 (7798): 270–273.
3. SARS-CoV-2 binding to ACE2 on human cells with at least 10x higher affinity than SARS-CoV. Wrapp, D., et al. Science 13 Mar 2020. Vol. 367( 6483): 1260-1263
4. Angiotensin receptor blockers have been proposed as tentative SARS-CoV-2 therapeutics. Gurwitz D (March 2020). "Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics". Drug Development Research
5. ACE2 has been shown to have a protective effect against virus-induced lung injury. Imai Y, et al. (July 2005). "Angiotensin-converting enzyme 2 protects from severe acute lung failure". Nature. 436 (7047): 112–6.
6. El-Tholoth, Mohamed; Bau, Haim H.; Song, Jinzhao (2020): A Single and Two-Stage, Closed-Tube, Molecular Test for the 2019 Novel Coronavirus (COVID-19) at Home, Clinic, and Points of Entry. ChemRxiv. Preprint.
7. Favipiravir (T-705), a Broad Spectrum Inhibitor of Viral RNA Polymerase. Furuta Y, et al. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(7):449-463.
8. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. Agostini ML, et al. mBio. 2018 Mar 6;9(2).
9. Remdesivir and Chloroquine Effectively Inhibit the Recently Emerged Novel Coronavirus (2019-nCoV) in Vitro. Wang M, et al. Cell Res. 2020 Mar;30(3):269-271.
10. Effect of Toll-Like Receptor 7 and 9 Targeted Therapy to Prevent the Development of Hepatocellular Carcinoma. Mohamed FE, et al. Liver Int. 2015 Mar;35(3):1063-76.
11. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Yao X, et al. Clin Infect Dis. 2020 Mar 9. pii: ciaa237.
12. Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy in Vivo. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40.
13. The Origin, Transmission and Clinical Therapies on Coronavirus Disease 2019 (COVID-19) Outbreak - An Update on the Status. Guo, Y., et al. Mil Med Res. 2020 Mar 13;7(1):11.
14. SARS Coronavirus Replicase Proteins in Pathogenesis. Graham RL, et al. Virus Res. 2008 Apr;133(1):88-100.
15. Characterization of the Receptor-Binding Domain (RBD) of 2019 Novel Coronavirus: Implication for Development of RBD Protein as a Viral Attachment Inhibitor and Vaccine. Wanbo Tai, et al. Cell Mol Immunol. 2020 Mar 19.
16. Coronaviruses: An Overview of Their Replication and Pathogenesis. Fehr AR, et al. Methods Mol Biol. 2015;1282:1-23.
17. SARS and MERS: Recent Insights Into Emerging Coronaviruses. de Wit E, et al. Nat Rev Microbiol. 2016 Aug;14(8):523-34.

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