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COVID-19 Reagents
The ongoing SARS-CoV-2 pandemic still requires immediate action from researchers around the globe. The virus attaches to cells by binding its outer spike proteins to the receptor protein ACE2 (angiotensin-converting enzyme 2), which is highly expressed on respiratory cells. ACE2 also acts as the receptor for the human respiratory coronavirus NL63 and the SARS-coronavirus (SARS-CoV). Studies have shown that the binding affinity of the viral spike protein for ACE2 correlates with higher transmissibility of the coronavirus and contagiousness of the disease. Researchers are investigating both antiviral drugs and vaccines to block infection and replication of the virus. [ ref. 1-5] Additionally, many scientists are looking into the ‘cytokine storm’, an excessive production of cytokines in response to the virus leading to adverse effects in the patient. Several of our suppliers offer tools to assist researchers who are investigating treatments and vaccines against COVID-19. In this section, we give you an overview of all corona-related research reagents that we offer.Products by categoryProducts by supplierClick on the logos and go directly to their products. Products by group/targetClick on the targets and go directly to the products. 
Antibodies are some of the most widely used research tools in life science. The specificity and affinity of these antibodies are of paramount importance for the success of a study. Bio-Connect offers a comprehensive portfolio of high quality antibodies directed against the different components of SARS-CoV-2 as well as ACE2, allowing you to find a suitable antibody for any application. Besides this, we offer many related antibodies, for example targeting SARS-CoV and other coronaviruses. The manufacturing partners put great effort into testing the quality of their products and support the five pillars of antibody validation. Most popular antibodies
| PK-AB718-3217 | ACE2 (CT) antibody (pAb) | | | | | PromoCell |
| HPA000288 | Anti-ACE2 | Rabbit | Polyclonal | Human | IHC, WB | Atlas Antibodies |
| AG-20A-0037B | anti-ACE2 (human), mAb (AC384) (Biotin) | | Monoclonal | Human | ELI, WB | AdipoGen Life Sciences |
| A3001 | Anti-SARS-CoV-2 Spike S1 Antibody (Clone# 4C7) | Mouse | Monoclonal | | ELISA | BioVision |
| GTX632604 | SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] | Mouse | Monoclonal | | WB, FACS | GeneTex |
| 40143-T62 | SARS-CoV Nucleoprotein / NP Antibody, Rabbit PAb, Antigen Affinity Purified | Rabbit | Polyclonal | | WB, ELISA, IHC-P, FCM, ICC/IF, IP | Sino Biological |
| 40150-T62-COV2 | SARS-CoV Spike Antibody, Rabbit PAb, Antigen Affinity Purified | Rabbit | Polyclonal | | WB, ELISA, IHC-P, FCM, ICC/IF, IP | Sino Biological |
| 40143-MM05 | SARS-CoV/SARS-CoV-2 Nucleocapsid Antibody, Mouse MAb | Mouse | Monoclonal | | WB, ELISA, IHC-P, FCM, ICC/IF, IP | Sino Biological |
| 40150-D001 | SARS-CoV/SARS-CoV-2 Spike Antibody, Chimeric MAb | Mouse | Monoclonal | | ELISA, IHC-P, FCM, ICC/IF, IP | Sino Biological |
| bsm-41411M | SARS-CoV-2 (1C7) Nucleocapsid protein Monoclonal Antibody | Mouse | Monoclonal | SARS-CoV-2 | | Bioss Antibodies |
| 40143-R019 | SARS-CoV-2 (2019-nCoV) Nucleocapsid Antibody, Rabbit MAb | Rabbit | Monoclonal | | WB, ELISA, IHC-P, FCM, ICC/IF, IP | Sino Biological |
| 40591-T62 | SARS-CoV-2 (2019-nCoV) Spike Antibody, Rabbit PAb, Antigen Affinity Purified | | | | | Sino Biological |
| 40592-MM57 | SARS-CoV-2 (2019-nCoV) Spike Neutralizing Antibody, Mouse Mab | Mouse | Monoclonal | | | Sino Biological |
| 40150-R007 | SARS-CoV-2 (2019-nCoV) Spike S1 Antibody, Rabbit MAb | Rabbit | Monoclonal | | ELISA, IHC-P, FCM, ICC/IF, IP | Sino Biological |
| 40590-T62 | SARS-CoV-2 (2019-nCoV) Spike S2 Antibody, Rabbit PAb, Antigen Affinity Purified | Rabbit | Polyclonal | | | Sino Biological |
| GTX635679 | SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344] | Rabbit | Monoclonal | | WB, ELISA | GeneTex |
| GTX135356 | SARS-CoV-2 (COVID-19) spike antibody | Rabbit | Polyclonal | | WB, ICC/IF | GeneTex |
| GTX635708 | SARS-CoV-2 (COVID-19) Spike S1 antibody [GT263] | Mouse | Monoclonal | | WB | GeneTex |
| GTX635654 | SARS-CoV-2 (COVID-19) Spike S1 antibody [HL6] | Rabbit | Monoclonal | | WB, ICC/IF, ELISA, sELISA | GeneTex |
| GTX100743 | TMPRSS2 antibody [N2C3] | Rabbit | Polyclonal | | WB | GeneTex |
More SARS-CoV-2 and related antibodies can be found in our webshop | As soon as the sequence of SARS-CoV-2 was determined in early 2020, the production of recombinant proteins was initiated. Recombinantly expressed protein is essential for investigation into the function of viral proteins and their separate subunits in COVID-19. Different parts of the coronavirus are investigated for potential treatment, production of preventive medicine or diagnostic kits. However, there is a particularly strong focus on the spike protein, which is mainly responsible for entry into the host cell. This protein is made up of several subunits, including the surface unit S1, transmembrane unit S2 and the receptor-binding domain (RBD). In addition to the spike protein, important components are the nucleocapsid protein of SARS-CoV-2 as well as the human ACE2 and TMPRSS receptors. Bio-Connect offers a comprehensive set of important SARS-CoV-2 and related proteins from several manufacturers. Most popular proteins
| AG-40B-0192B | ACE2 (human) (rec.) (Biotin) | | AdipoGen Life Sciences |
| 10108-H08H | Human ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) | His tag | Sino Biological |
| 40605-V08B | Human coronavirus (HCoV-229E) Spike Protein (S1+S2 ECD, His Tag) | His tag | Sino Biological |
| 40604-V08B | Human coronavirus (HCoV-NL63) Spike Protein (S1+S2 ECD, His Tag) | His tag | Sino Biological |
| 40607-V08B | Human coronavirus (HCoV-OC43) Spike Protein (S1+S2 ECD, His Tag) | His tag | Sino Biological |
| 40606-V08B | Human coronavirus HKU1 (isolate N5) (HCoV-HKU1) Spike Protein (S1+S2 ECD, His Tag) | His tag | Sino Biological |
| 40588-V08B | SARS-CoV-2 (2019-nCoV) Nucleocapsid Protein (His tag) | His tag | Sino Biological |
| 40592-V08B | SARS-CoV-2 (2019-nCoV) Spike Protein (RBD, His Tag) | His tag | Sino Biological |
| 40592-V08H | SARS-CoV-2 (2019-nCoV) Spike Protein (RBD, His Tag) | His tag | Sino Biological |
| 40592-V05H | SARS-CoV-2 (2019-nCoV) Spike Protein (RBD, mFc Tag) | mFc Tag | Sino Biological |
| 40591-V08B1 | SARS-CoV-2 (2019-nCoV) Spike Protein (S1 Subunit, His tag) | His tag | Sino Biological |
| 40591-V08H | SARS-CoV-2 (2019-nCoV) Spike Protein (S1 Subunit, His Tag) | His tag | Sino Biological |
| 40591-V05H1 | SARS-CoV-2 (2019-nCoV) Spike Protein (S1 Subunit, mFc Tag) | mFc Tag | Sino Biological |
| 40589-V08B1 | SARS-CoV-2 (2019-nCoV) Spike Protein (S1+S2 ECD, His tag) | His tag | Sino Biological |
| 40590-V08B | SARS-CoV-2 (2019-nCoV) Spike Protein (S2 ECD, His tag) | His tag | Sino Biological |
| 40592-VNAH | SARS-CoV-2 (2019-nCoV) Spike RBD Recombinant Protein | | Sino Biological |
| 40592-V05H1 | SARS-CoV-2 (2019-nCoV) Spike RBD-mFc (V367F) Recombinant Protein | | Sino Biological |
| 40591-V08H3 | SARS-CoV-2 (2019-nCoV) Spike S1(D614G)-His Recombiant Protein | | Sino Biological |
| 40591-V08H-B | SARS-CoV-2 (2019-nCoV) Spike S1-His Recombinant Protein, Biotinylated | | Sino Biological |
| GTX135357-pro | SARS-CoV-2 (COVID-19) nucleocapsid protein | | GeneTex |
More SARS-CoV-2 and related proteins can be found in our webshop
| One of the early responses to the pandemic caused by SARS-CoV-2 was to start testing a large amount of individuals who showed symptoms of COVID-19. The ability to identify and isolate patients has proven an important factor in preventing further spread of the disease. Detection of the virus can be done in several ways, depending on the laboratory performing them and the origin of the sample. At the moment, the most common tests are based on either finding the viral RNA by RT-PCR or identifying antibodies against the viral particles. Testing materials quickly became a scarcity as the virus spread, and many companies have dedicated their production to producing separate reagents or complete kits. The CE-IVD mark is used specifically for kits that conform to the health and safety standards for in vitro diagnostics in Europe. Also crucial in testing patients for coronavirus is adequate sample handling, which ensures that viral material is preserved until the actual test is performed. Therefore it is necessary to use dedicated materials for transportation and preparation of the samples. Finally, next to identifying viral components, detection assays are necessary to look into, for example, the activity of ACE2 and inhibitors. These kinds of assays will allow advances in the fields of medicine against COVID-19. Our diagnostics division also offers various SARS-CoV-2 detection kits, such as rapid tests, PCR kits, and ELISA kits, including the iLAMP Novel CoV19 iONEBIO FICS.Most popular detection assays
| orb639446 | 1copy COVID-19 qPCR Kit CE IVD | | Biorbyt |
| RK04138 | 2019-nCoV Spike S1 Protein IgG Antibody Elisa Kit | The ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of samples in serum, plasma (EDTA, citrate, heparin).
| ABclonal |
| AG-45B-0023 | ACE2 (human) ELISA Kit | Measure soluble ACE2 levels in serum, plasma, urine and cell culture supernatants. Soluble ACE2 may act as a competitive interceptor of SARS-CoV-2 and as biomarker. | AdipoGen Life Sciences |
| PK-CA577-K310 | ACE2 Inhibitor Screening Kit | Simple fluorometric assay that can be used to identify and characterize Angiotensin II Converting Enzyme inhibitors/activators in a high-throughput format. | PromoCell |
| 3103010006 | ANDiS Viral Nucleic RNA Auto Extraction & Purification Kit | ANDiS Viral RNA Auto Extraction & Purification Kit can efficiently purify the viral genome from different samples. The extracted sample is suitable for use in dowsnstream molecular diagnostic and detection applications. When used together with the ANDiS 350 Automated Nucleic Acid Extraction System, the process can be completed within 40 minutes, with up to 38 minutes of walkaway time. | ABclonal |
| W-IgM/IgG-20 | COVID-19(SARS-CoV-2) IgM/IgGAntibody Test Kit | | ABclonal |
| RR-0479-02 | Liferiver Novel Coronavirus (2019-nCoV) Real Time Multiplex RT-PCR Kit | Novel Coronavirus (2019-nCoV) Real Time Multiplex RT-PCR Kit (Detection for 3 Genes) is used for the in vitro qualitative detection of 2019 novel coronavirus (2019-nCoV) RNA in upper respiratory tract specimens (nasopharyngeal and oropharyngeal extracts) and lower respiratory tract specimens (bronchoalveolar lavage fluid (BALF) and deep cough sputum) by real time PCR systems. It is considered as an aid in the diagnosis of the 2019-nCoV infection. | BioVendor |
| 1N38C2 | Rapid 2019-nCoV IgG/IgM Combo Test | Rapid 2019-nCoV IgG/IgM Combo Test Card is an immunochromatography based one step in vitro test. It is designed for the rapid qualitative determination of IgG and IgM antibodies to 2019 novel coronavirus (2019-nCoV, SARS-CoV-2) in human serum, plasma, or whole blood. | BioVendor |
| KIT40588 | SARS-CoV-2 (2019-nCoV) Nucleoprotein / NP ELISA Kit (incubation time 20 min) | This kit is an ELISA for the quantitative measurement of 2019-nCoV coronavirus nucleocapsid protein in recombinant protein. It contains recombinant 2019-nCoV coronavirus nucleocapsid, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. | Sino Biological |
| KIT40591 | SARS-CoV-2 (2019-nCoV) Spike ELISA Kit (incubation time 20 min) | This kit is an ELISA for the quantitative measurement of 2019-nCoV Coronavirus spike protein. It contains recombinant 2019-nCoV Coronavirus spike, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. | Sino Biological |
| AG-45B-0020 | SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit (incl. False Positive Control Plate) | This sensitive and specific SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit can be used for the qualitative measurement of human Immunoglobulin G (IgG) against SARS-CoV-2 Spike (Receptor Binding Domain) protein in serum and plasma samples. | AdipoGen Life Sciences |
| AG-48B-0001 | SARS-CoV-2 Inhibitor Screening Kit | The SARS-CoV-2 Inhibitor Screening Kit contains key reagents required to facilitate identification of SARS-CoV-2 inhibitors. This inhibitor screen is based on a colorimetric ELISA kit, which measures the binding of the RBD of the Spike S protein from SARS-CoV-2 to its human receptor ACE2. This assay allows to identify and characterize the effect of different inhibitory molecules including antibodies or chemicals on the prevention of binding of SARS-CoV-2 virus to any ACE2-expressing cells. | AdipoGen Life Sciences |
| AG-48B-0002 | SARS-CoV-2 Neutralizing Antibodies Detection Kit | Detect the presence of neutralizing antibodies against SARS-CoV-2 in serum/plasma independently of species and isotypes. | AdipoGen Life Sciences |
| 41A225 | SARS-CoV-2 NP Ab ELISA (CE IVD) | For the detection and qualitative measurement of total antibodies against the nucleocapsid protein (NP) of SARS-CoV-2 virus in human blood. | BioVendor |
| 41A222 | SARS-CoV-2 NP IgG ELISA (CE IVD) | For the detection and qualitative measurement of IgG class antibodies against the nucleocapsid protein (NP) of SARS-CoV-2 virus in human blood. | BioVendor |
| 41A224 | SARS-CoV-2 NP IgM ELISA (CEIVD) | For the detection and qualitative measurement of IgM class antibodies against the nucleocapsid protein (NP) of SARS-CoV-2 virus in human blood. | BioVendor |
| W-2019-nCov-100 | SARS-CoV-2 Nucleic Acid Test Kit | | ABclonal |
| 08-65-00250 | SOLIScript 1-step CoV Kit | This kit is optimized for probe based one-step RT real-time quantitative PCR assays. It contains all the components necessary (except template, primers, and probes) to perform cDNA synthesis and probe based qPCR in a single tube. | Solis BioDyne |
| 70406 | Viral DNA/RNA Isolation Kit | This kit allows manual and automated extraction of DNA and RNA from viruses in cell-free samples, such as serum and plasma. The extraction process utilizes superparamagnetic microspheres without centrifugation. Extracted products can be used for digestion, PCR amplification, detection and other follow-up experiments. | ABclonal |
| 43903 | Viral Transport System | The Beaver Viral Transport System enables clinical specimens containing viruses, including SARS-CoV-2, chlamydia, mycoplasma, ureaplasma, to be collected, transported and stored at room temperature for up to one week before DNA/RNA isolation. The 43903 can be used in throat swabs and nasal swabs. | ABclonal |
More SARS-CoV-2 assay and rapid test kits can be found in our webshop
| To date, treatment of patients with severe COVID-19 is limited, as potential therapies are still in the trial phases. Researchers are looking for antivirals that inhibit infection or replication of the coronavirus, as well as immunomodulatory compounds. The latter is relevant because many patients experience an overwhelming and sometimes deadly production of proinflammatory cytokines, known as the cytokine storm. Bio-Connect offers several compounds that can potentially alter the immune response in COVID-19 patients, such as Tocilizumab, which is a monoclonal antibody blocking the IL-6 receptor. We also offer promising agents relevant to antiviral research, such as Remdesivir (GS-5734), Camostat mesylate (TMPRSS2) and Favipiravir (T-705). These compounds are being investigated for their interference with SARS-CoV-2 and closely related viruses in the human body. On this page, you will also find compounds that are more distantly related to infectious diseases and have the potential to be effective in SARS-CoV-2 infection. Many of these compounds have already been approved for treatment of other diseases and therefore provide a strong advantage over new compounds, which would have to go through thorough safety testing. Finally, we offer an Anti-COVID-19 Compound Library (HY-L052) from MedChemExpress. Most popular chemicalsWhen investigating COVID-19 or producing kits for fellow researchers, it may be necessary to produce the individual proteins of SARS-CoV-2 or the host in a specific, controlled expression system. Cloning these expression vectors tends to be tedious and time consuming. Therefore, Bio-Connect offers a large number of ready-to-go viral gene products as well as plasmids containing the sequence for human proteins involved in infection. All plasmids come with several options of tags. If you cannot find the right plasmid, do not hesitate to send a custom cloning request for a plasmid that will perfectly suit your needs. It is also possible to reconstitute live virus of any coronavirus species, wild-type or mutated version, by transfecting a coronavirus vector into the proper packaging cells. Most popular plasmids
VectorBuilder’s coronavirus vector system allows users to reconstitute live virus of any coronavirus species – wild-type or mutated version – by simply transfecting the vector into the proper packaging cells. The resulting virus can be further propagated and amplified to any quantity in the appropriate cell line. They also offer a variety of lentivirus vectors pseudotyped with S proteins from a wide range of coronavirus species. Different vectors can be used to express different reporters, such as EGFP or luciferase, allowing the monitoring of viral entry into host cells by a variety of means. VectorBuilder also offers VSV Pseudotyped with Coronavirus S protein. They will assist you with the design and have unlimited customization options. It provides a safe alternative to live SARS-CoV-2 virus for studying S protein-mediated entry into host cells. Additionally, you can use bald VSV, lacking the viral envelope, as a negative control. Design your own vector or send vector design request for:- Coronavirus vectors- Lentivirus pseudotyped with Coronavirus S protein- VSV Pseudotyped with Coronavirus S protein- Cell line models for coronavirus research- Animal models for coronavirus researchUse the code "BioConnect_15%Off_2020" to get a 15% discount on your order.
- ACE2 is the receptor for SARS (SARS-CoV). Li, W. et al., EMBO J (2005)24:1634-1643
- ACE2 is the receptor for the new virus, SARS-CoV-2. Zhou P, et al. (March 2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin". Nature. 579 (7798): 270–273.
- SARS-CoV-2 binding to ACE2 on human cells with at least 10x higher affinity than SARS-CoV. Wrapp, D., et al. Science 13 Mar 2020. Vol. 367( 6483): 1260-1263
- Angiotensin receptor blockers have been proposed as tentative SARS-CoV-2 therapeutics. Gurwitz D (March 2020). "Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics". Drug Development Research
- ACE2 has been shown to have a protective effect against virus-induced lung injury. Imai Y, et al. (July 2005). "Angiotensin-converting enzyme 2 protects from severe acute lung failure". Nature. 436 (7047): 112–6.
- El-Tholoth, Mohamed; Bau, Haim H.; Song, Jinzhao (2020): A Single and Two-Stage, Closed-Tube, Molecular Test for the 2019 Novel Coronavirus (COVID-19) at Home, Clinic, and Points of Entry. ChemRxiv. Preprint.
- Favipiravir (T-705), a Broad Spectrum Inhibitor of Viral RNA Polymerase. Furuta Y, et al. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93(7):449-463.
- Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. Agostini ML, et al. mBio. 2018 Mar 6;9(2).
- Remdesivir and Chloroquine Effectively Inhibit the Recently Emerged Novel Coronavirus (2019-nCoV) in vitro. Wang M, et al. Cell Res. 2020 Mar;30(3):269-271.
- Effect of Toll-Like Receptor 7 and 9 Targeted Therapy to Prevent the Development of Hepatocellular Carcinoma. Mohamed FE, et al. Liver Int. 2015 Mar;35(3):1063-76.
- in vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Yao X, et al. Clin Infect Dis. 2020 Mar 9. pii: ciaa237.
- Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy in vivo. Lamphier M, et al. Mol Pharmacol. 2014 Mar;85(3):429-40.
- The Origin, Transmission and Clinical Therapies on Coronavirus Disease 2019 (COVID-19) Outbreak - An Update on the Status. Guo, Y., et al. Mil Med Res. 2020 Mar 13;7(1):11.
- SARS Coronavirus Replicase Proteins in Pathogenesis. Graham RL, et al. Virus Res. 2008 Apr;133(1):88-100.
- Characterization of the Receptor-Binding Domain (RBD) of 2019 Novel Coronavirus: Implication for Development of RBD Protein as a Viral Attachment Inhibitor and Vaccine. Wanbo Tai, et al. Cell Mol Immunol. 2020 Mar 19.
- Coronaviruses: An Overview of Their Replication and Pathogenesis. Fehr AR, et al. Methods Mol Biol. 2015;1282:1-23.
- SARS and MERS: Recent Insights Into Emerging Coronaviruses. de Wit E, et al. Nat Rev Microbiol. 2016 Aug;14(8):523-34.
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