AdipoGen Life Sciences

AdipoGen Life Sciences, Inc. is a well-established manufacturer and worldwide distributor of innovative and high quality products focusing on advanced inflammation, immune response & immunometabolic research. Production is located in Switzerland, the US and Germany. A motivated team of highly-skilled individuals develops and manufactures new products for the life science research market. They focus their efforts on inflammation and immune response, including inflammasomes, innate immunity, B- and T-cells immune regulation, neuroinflammation, obesity and immuno-oncology. AdipoGen Life Sciences owns chemical laboratories, enabling the company to isolate unique natural products, to develop new and innovative small molecules, and to manufacture rare antibiotics.

AdipoGen Life Sciences cooperates with a number of manufacturers such as: Ancell Corporation, BioViotica, Chemodex, Chimerigen Laboratories, Innaxon, JaICA and South Bay Bio.

Bio-Connect Life Sciences supplies all their products in the Benelux. If you have any questions, please contact the helpdesk.

Major product lines from AdipoGen Life Sciences

• Antibodies (Special focus: functional antibodies & recombinant antibodies (Non-animal source))
• Recombinant proteins
• ELISA kits & matched pair detection sets
• Small molecules (biochemicals) / natural products / rare antibiotics

Top sellers

MultimericCD40L – Highly potent B Cell expansion reagent

MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to [CD40L+enhancer] combinations. MultimericCD40L™ has shown to suppress alum-induced IL-1β release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.

Figure: CD40L (human) (multimeric) (rec.) (AG-40B-0010) does not need an enhancer to induce B cell activation.

InVivoKines™

Proteins with Enhanced Activity & Stability for lnVivo Research

lnVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. lnVivoKines™ are Fc-based fusion proteins using the Knobs-into-Holes (KlH) technology. Read more

lnVivoKines™ Quality Features

• Native Conformation – Production in HEK 293 or CHO cells
• Production under Animal-Free Conditions
• High Bioactivity tested by ELISA/Cell-based Assays
• Verified Purity & Homogeneity by SEC
• Low Endotoxin Levels
• Batch -to-Batch Consistency

Publications with products by AdipoGen Life Sciences

• Haselmayer P, Vigolo M, Nys J, Schneider P, Hess H. A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells. Eur J Immunol. 2017;47(6):1075-1085.
• Kowalczyk-Quintas C, Schuepbach-Mallepell S, Vigolo M, et al. Antibodies that block or activate mouse b cell activating factor of the tumor necrosis factor (Tnf) family (Baff), respectively, induce b cell depletion or b cell hyperplasia. J Biol Chem. 2016;291(38):19826-19834.
• Eslami M, Meinl E, Eibel H, et al. Baff 60-mer, and differential baff 60-mer dissociating activities in human serum, cord blood and cerebrospinal fluid. Front Cell Dev Biol. 2020;8:577662.
• Kume M, Kiyohara E, Matsumura Y, et al. Ganglioside gd3 may suppress the functional activities of benign skin t cells in cutaneous t-cell lymphoma. Front Immunol. 2021;12:651048.
• Singh K, Kadesjö E, Lindroos J, et al. Interleukin-35 administration counteracts established murine type 1 diabetes–possible involvement of regulatory T cells. Sci Rep. 2015;5:12633.
• Ellisdon AM, Nold-Petry CA, D’Andrea L, et al. Homodimerization attenuates the anti-inflammatory activity of interleukin-37. Sci Immunol. 2017;2(8).
• Ising C, Venegas C, Zhang S, et al. NLRP3 inflammasome activation drives tau pathology. Nature. 2019;575(7784):669-673.
• Müller K, Girl P, von Buttlar H, Dobler G, Wölfel R. Comparison of two commercial surrogate ELISAs to detect a neutralising antibody response to SARS-CoV-2. J Virol Methods. 2021;292:114122.
• Zheng M, Karki R, Vogel P, Kanneganti T-D. Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense. Cell. 2020;181(3):674-687.e13.
• Sellami L, Rucheton B, Ben Younes I, et al. Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience. Neurobiol Aging. 2020;91:167.e1-167.e9.
• Schneider KS, Groß CJ, Dreier RF, et al. The inflammasome drives gsdmd-independent secondary pyroptosis and il-1 release in the absence of caspase-1 protease activity. Cell Rep. 2017;21(13):3846-3859.

Downloads

Functional Antibodies | Focus: Recombinant Antibodies
Proteins with Enhanced Activity & Stability
ELISA Kits
Rare Antibiotics & Unique Natural Products
InVivoKines™

Read more about AdipoGen’s products

Inflammasomes
GLP-1, GIP & GCG in Obesity and Diabetes Research
Proteins with Enhanced Activity
Non-Animal Source Antibodies