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Integrins and Integrin Antibodies

Integrins are a family of transmembrane receptor proteins, connecting the cytoskeleton and extracellular matrix (ECM). They bind to ECM glycoproteins including collagens, fibronectins, laminins, and a number of cellular receptors. In addition, integrins function as signal transducers. The different integrins activate differential intracellular signaling pathways that control biological and cellular functions including cell adhesion, migration, proliferation, cell differentiation and apoptosis.

Atlas offers antibodies targeting integrin alpha and beta subunits. The integrin antibodies have been evaluated in one or more of the IHC, WB and ICC-IF applications.

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Introducing InVivoMAb anti-mouse CD172a (SIRPα)

The P84 monoclonal antibody reacts with Signal-Regulatory Protein α (SIRPα), also known as CD172a. SIRPα is a type I transmembrane glycoprotein expressed on monocytes, macrophages, and dendritic cells. Neurons and other tissues of the central nervous system have also been shown to express SIRPα.

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